Triple-Layered Core-Shell Fiber Dressings with Enduring Platelet Conservation and Sustained Growth Factor Release Abilities for Chronic Wound Healing

The study developed triple-layered core-shell fiber dressings for chronic wound healing, using 45 rats with full-thickness skin wounds. These dressings conserve platelets and sustain growth factor release, crucial for effective healing. Made from chitosan, alginate, and gelatin, they demonstrate excellent water absorption, antibacterial activity, and biocompatibility. The fibers maintain platelet activity for up to 180 days and modulate growth factor release, such as VEGF, essential for wound healing. Rapid freezing and trehalose protect PRP activity, while the fibers show significant antibacterial properties and promote cell proliferation. This innovative dressing offers a promising solution for long-term wound treatment.