Platelet Extracellular Vesicles Loaded Gelatine Hydrogels for Wound Care

The study investigates the use of gelatine-based hydrogels loaded with platelet extracellular vesicles (pEVs) for improved wound healing, particularly in diabetic and chronic wounds. The optimal hydrogel formulation, PAH0.24G37, demonstrated mechanical stability, high cell viability, and effective swelling properties, making it suitable for wound dressing. In diabetic rat models, the PAH0.24G37@pEVs formulation achieved complete wound closure within 14 days, attributed to the synergistic effects of the hydrogel and pEVs in promoting tissue repair, angiogenesis, and reducing inflammation. The study confirms the safety of the treatment with no toxicity observed in major organs, although challenges remain in translating these findings to clinical applications, including long-term safety, potential immunogenic responses, and standardization of pEVs production.