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Differences in Cell Subsets Between Sun-Exposed and Unexposed Skin: Preliminary Single-Cell Sequencing and Biological Analysis from a Single Case

research Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case

3 citations , October 2024 in “Frontiers in Medicine”

This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.

research Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study

October 2023 in “Cancers”

In this retrospective study, patients with cutaneous squamous cell carcinoma located in highly sun-exposed areas had a higher risk of local recurrence compared to those with tumors in less sun-exposed areas, though metastasis rates did not differ between the groups.

research Anatomic location of primary melanoma: Survival differences and sun exposure

27 citations , April 2019 in “Journal of The American Academy of Dermatology”

This study found that melanoma on the posterior scalp is associated with worse survival compared to other body sites, while sun-exposed areas showed better survival outcomes.

Unexpected Expression of Hemoglobin Alpha as an Endogenous Antioxidant in Epidermal Keratinocytes

research 532 Unexpected expression of hemoglobin α as an endogenous antioxidant in epidermal keratinocytes

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that hemoglobin α is upregulated in epidermal keratinocytes after UV exposure and may function as an antioxidant, particularly for hair follicle stem cells.

research Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

June 2021

This study found that chronic UVR exposure in mice and humans leads to a permanent loss of papillary fibroblasts in the upper dermis, which is associated with changes in the extracellular matrix.

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Community Join

5 / 406 results

community Going bald is a genuine health issue.

100 upvotes 3 weeks ago

Bald people have a higher risk of skin cancer, especially on the scalp, and wearing a hat is suggested as a solution. Hair loss treatments like Minoxidil, finasteride, and RU58841 are not mentioned in this conversation.

community Is it safe to use Minoxidil and Retinol at the same time?

4 upvotes 5 years ago

Using Minoxidil and Retinol together is generally safe, but caution is advised if adding Retinol to a topical hair solution, as excessive Retinol can lead to hair loss, especially with sun exposure.

community Finasteride and “anti-aging” effects

in Treatment 218 upvotes 1 year ago

Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.

community The Health Benefits of Head Hair

in Research/Science 19 upvotes 11 months ago

Hair provides protection against head trauma, reduces skin cancer risk, helps remove heavy metals, and aids in wound healing. The conversation emphasizes the health benefits of maintaining head hair beyond cosmetic reasons.

community for those who use oral minoxidil, did it age your face?

44 upvotes 2 years ago

Oral minoxidil may cause facial puffiness or aging in some users, but results vary. Many users experience positive hair growth and stress the importance of skincare and a healthy lifestyle.

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