Single-Cell Transcriptomics Reveals a Senescence-Associated IL-6/CCR6 Axis Driving Radiodermatitis

    July 2022 in “ EMBO molecular medicine ”
    Mor Paldor, Orr Levkovitch-Siany, Dana Eidelshtein … Jonathan H. Axelrod
    Studysummary This study found that targeting IL-6, IL-1, and CCR6 signaling pathways may effectively reduce irradiation-induced alopecia and dermatitis in radiotherapy patients.
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    Research cited in this study 9

    1. Single-Cell Transcriptomics Reveals a Senescence-Associated IL-6/CCR6 Axis Driving Radiodermatitis EMBO molecular medicine · 2022
    2. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    3. Age-Associated Inflammation Connects RAS-Induced Senescence to Stem Cell Dysfunction and Epidermal Malignancy Cell death and differentiation · 2015
    4. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    5. Mechanisms Regulating Skin Immunity and Inflammation Nature Reviews Immunology · 2014
    6. Permanent Alopecia After Cranial Irradiation: Dose–Response Relationship International journal of radiation oncology, biology, physics · 2004
    7. A Phase I Study of Topical Tempol for the Prevention of Alopecia Induced by Whole Brain Radiotherapy Clinical Cancer Research · 2004
    8. Animal and In Vitro Models for the Study of Hair Follicles Journal of Investigative Dermatology Symposium Proceedings · 2003
    9. Growth of the Hair Physiological Reviews · 1954