Integrated Transcriptomic and Proteomic Analysis Reveals Molecular Mechanisms of Melatonin-Regulated Hair Follicle Growth in Cashmere Goats and Comparative Insights Across Goat Breeds
November 2025
in “
BMC Genomics
”
Research cited in this study
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research Microinjury-Induced Tumor Necrosis Factor-Alpha Surge Stimulates Hair Regeneration in Mice
Minor injuries to hair follicles can stimulate hair growth in mice by increasing a specific protein.
research Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State
Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
research Shedding Light on Cashmere Goat Hair Follicle Biology: From Morphology Analyses to Transcriptomic Landscape
The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.
research Screening the Key Genes of Hair Follicle Growth Cycle in Inner Mongolian Cashmere Goat Based on RNA Sequencing
Researchers identified genes that may affect hair growth in Cashmere goats.
research Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells
Wnt signaling is crucial for skin development and hair growth.
research Wool Keratin-Associated Protein Genes in Sheep: A Review
Understanding wool keratin-associated proteins in sheep can help improve wool quality through selective breeding.
research SFRP2 Augments Wnt/β-Catenin Signalling in Cultured Dermal Papilla Cells
SFRP2 boosts Wnt3a/β-catenin signals in hair growth cells, with stronger effects in beard cells than scalp cells.
research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth
Blocking JAK-STAT signaling can lead to hair growth.
research Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence
Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.
research Influence of Feed Restriction on the Wool Proteome: A Combined iTRAQ and Fiber Structural Study
Feed restriction in sheep leads to finer wool fibers but may reduce wool quality.
research Signaling Involved in Hair Follicle Morphogenesis and Development
The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.
research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling
The study found key genes and pathways involved in cashmere goat hair growth stages.
research Differential Gene Expression Analysis Between Anagen and Telogen of Capra Hircus Skin Based on the De Novo Assembled Transcriptome Sequence
Signaling pathways are crucial for hair growth in goats.
research VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway
VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.
research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation
TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.
research Annotation of Sheep Keratin Intermediate Filament Genes and Their Patterns of Expression
Sheep have 17 keratin genes, similar to humans, but with different expression patterns affecting wool and hair.
research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation
HOXC13 is essential for hair and nail development by regulating Foxn1.
research Characterization and Expression Analysis of KAP7.1 and KAP8.2 Genes in Liaoning New-Breeding Cashmere Goat Hair Follicles
KAP7.1 and KAP8.2 genes are crucial for cashmere quality in goats.
research Expression Patterns of Keratin Intermediate Filament and Keratin Associated Protein Genes in Wool Follicles
Gene expression in wool follicles changes with growth cycles, offering insights into wool and human hair growth.
research Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling
Dlx3 is essential for hair growth and regeneration.
research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion
BMP signaling prevents hair growth by stopping stem cell activation.
research BMP Signaling in the Control of Skin Development and Hair Follicle Growth
BMP signaling is crucial for skin and hair growth.
research Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle
Inhibiting Bmp signaling disrupts hair growth and differentiation.
research Melatonin and Fleece Growth in Australian Cashmere Goats
Melatonin implants affect the growth and pattern of cashmere goat fleece depending on the time of year they are given.
research Effect of Immunization Against Melatonin on Seasonal Fleece Growth in Feral Goats
Immunizing goats against melatonin can temporarily change their cashmere growth cycles and increase fleece production.