Correlation Analysis of CXCL10, FOS, HOXC13, and WNT4 Gene Polymorphisms with Key Economic Traits: Initial Population Screening for Jiangnan Cashmere Goats

    September 2025 in “ Genes ”
    Gvlnigar Amar, Qiumin Lu, Asma Anwar … Xuefeng Fu
    Studysummary In this study, researchers reported that specific gene polymorphisms in Jiangnan cashmere goats, particularly SNPs in the <i>HOXC13</i> and <i>WNT4</i> genes, were significantly associated with key economic traits like birth weight and yearling weight, providing molecular markers for breeding and enhancing economic trait stability.
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    Research cited in this study 11

    1. Drivers of Plateau Adaptability in Cashmere Goats Revealed by Genomic and Transcriptomic Analyses BMC genomics · 2023
    2. Correlation Analysis of Four KRTAP Gene Polymorphisms and Cashmere Fiber Diameters in Two Cashmere Goat Breeds Canadian journal of animal science · 2022
    3. Effect of the FA2H Gene on Cashmere Fineness of Jiangnan Cashmere Goats Based on Transcriptome Sequencing BMC Genomics · 2022
    4. Skin Transcriptome Profiling of Changthangi Goats Highlights the Relevance of Genes Involved in Pashmina Production Scientific reports · 2020
    5. Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development Molecular Biology of the Cell · 2018
    6. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats PLoS ONE · 2016
    7. Loss-Of-Function Mutations In HOXC13 Cause Pure Hair And Nail Ectodermal Dysplasia The American Journal of Human Genetics · 2012
    8. Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    9. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    10. HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression Journal of Biological Chemistry · 2002
    11. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998