Author Response: Quantitative Mapping of Human Hair Greying and Reversal in Relation to Life Stress

The study explored the molecular features of reversible hair greying in humans and its connection to psychological stress. It highlighted changes in mitochondrial energy metabolism and fatty acid metabolism associated with hair pigmentation loss. However, no psychosocial stress-related hormones or canonical markers of senescence were detected in the hair fibers. The study's findings were primarily correlative and suggested the need for more in-depth mechanistic studies and larger sample sizes to confirm the results. The research represented a significant methodological advance and set the stage for future investigations into the biological embedding of stress.