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Did you mean Immune Cell Infiltration?

GlossaryImmune Cell Infiltration

movement of immune cells into tissues responding to damage or infection

Immune cell infiltration refers to the process where immune cells, such as T cells and macrophages, move into a tissue or organ, often in response to infection, injury, or disease. This can be a sign of the body's attempt to fight off pathogens or repair damage, but in some cases, like autoimmune diseases, it can lead to tissue damage and inflammation.

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research A Signature of Genes Including FGF11 Reveals Aberrant Fibroblast Activation and Immune Infiltration in Keloid Tissue

2 citations, August 2022 in “Emergency medicine international”

Keloid skin disorder involves abnormal fibroblast activation and immune response, linked to a group of genes including FGF11.

research Loss of UBE2N in Keratinocytes Leads to Skin Inflammation and Immune Infiltration Through IRAK1/4-Mediated Processes

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Removing UBE2N from skin cells causes inflammation and immune response, which can be lessened with specific inhibitors.

research Investigation of Hub Genes and Immune Infiltration in Androgenetic Alopecia Using Bioinformatics Analysis

November 2022 in “Annals of Translational Medicine”

Immune activities and specific genes are important in male pattern baldness.

research Spatial Transcriptome Reveals Disturbance of Peri-Infundibular Immune Infiltration in Androgenetic Alopecia

June 2023 in “Research Square (Research Square)”

Hair loss in male pattern baldness is linked to changes in immune cell behavior around hair follicles.

research Identification and Characterization of Four Immune-Related Signatures in Keloid

11 citations, July 2022 in “Frontiers in Immunology”

Four specific genes are linked to keloid formation and could be potential treatment targets.

Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

research Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

3 citations, May 2023 in “Precision clinical medicine”

Researchers found four genes that could help diagnose severe alopecia areata early.

research Transcriptome Analysis of Frontal Fibrosing Alopecia Revealed Involvement of Immune Cells and Ferroptosis

February 2024 in “Skin research and technology”

The research suggests that immune cells and a specific type of cell death called ferroptosis are involved in Frontal fibrosis alopecia.

research Identification of Distinct Immune Signatures and Chemokine Networks in Scalp Inflammatory Diseases

June 2023 in “Research Square (Research Square)”

Different immune responses cause hair loss in scalp diseases, with unique patterns in scalp psoriasis possibly protecting against hair loss.

research Disturbance of Immune Microenvironment in Androgenetic Alopecia Through Spatial Transcriptomics

August 2024 in “International Journal of Molecular Sciences”

Androgenetic alopecia involves immune cell disruptions, especially increased CD4+ T cells around hair follicles.

research Age-Associated Inflammation Connects RAS-Induced Senescence to Stem Cell Dysfunction and Epidermal Malignancy

56 citations, March 2015 in “Cell death and differentiation”

Older skin has higher cancer risk due to inflammation and stem cell issues.

research Loss of Epidermal Evi/Wls Results in a Phenotype Resembling Psoriasiform Dermatitis

51 citations, August 2013 in “The Journal of experimental medicine/The journal of experimental medicine”

Loss of a specific protein in skin cells causes symptoms similar to psoriasis.

research Identification of Ferroptosis-Related Biomarkers in Alopecia Areata Through Machine Learning

February 2024 in “Scientific reports”

Four genes are potential markers for hair loss condition alopecia areata, linked to a specific type of cell death.

research The Protective Role of miR-486 for Alopecia Areata

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

miR-486 may help prevent hair loss in alopecia areata.

research Methods in Inflammatory Hair Disease Research: Enhanced Multiplex Imaging on Alopecia Areata Tissue Sections

December 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

New imaging technology can show up to 40 different markers in hair loss tissue, helping to understand hair disease better.

research Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis

February 2022 in “Research Square (Research Square)”

High TSPEAR levels in colorectal cancer predict worse outcomes.

research Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis

January 2022 in “Research Square (Research Square)”

High TSPEAR levels in colorectal cancer predict worse outcomes.

research Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice

March 2024 in “International journal of molecular sciences”

taVNS reduces vitiligo symptoms in mice.

research Immune Modulation of Hair Follicle Regeneration

29 citations, May 2020 in “npj Regenerative Medicine”

Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.

research The Developing Immune Network in Human Prenatal Skin

11 citations, March 2020 in “Immunology”

Human prenatal skin develops an immune network early on that helps with skin formation and healing without scarring.

research A Human Prenatal Skin Cell Atlas Reveals Immune Cell Regulation of Skin Morphogenesis

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Immune cells are essential for early hair and skin development and healing.

research Does Mitochondrial Dysfunction Drive Immune Privilege Collapse in Lichen Planopilaris Pathogenesis?

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mitochondrial dysfunction may contribute to chronic inflammation and immune system issues in Lichen planopilaris.

research Activating an Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative Wound Healing

328 citations, November 2020 in “Nature Materials”

Hydrogel scaffolds can help wounds heal better and grow hair.

research Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia

September 2023 in “Medicine”

The research suggests immune system changes and specific gene expression may contribute to male hair loss, proposing potential new treatments.

research Understanding Autoimmunity of Vitiligo and Alopecia Areata

74 citations, May 2016 in “Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics”

Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.

Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis

research Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis

December 2022 in “Research Square (Research Square)”

Key genes linked to immune response are upregulated in hair follicles and skin tissues in chronic discoid lupus erythematosus.

research Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis

October 2022 in “Research Square (Research Square)”

Key genes linked to immune response are highly active in lupus-affected hair follicles.

research The Coenzyme A Precursor Pantethine Enhances Antitumor Immunity in Sarcoma

1 citations, October 2023 in “Life science alliance”

Pantethine may boost the immune system's ability to fight sarcoma.

research Fatty Acids and Related Lipid Mediators in the Regulation of Cutaneous Inflammation

28 citations, January 2018 in “Biochemical Society Transactions”

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms Behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin with Marilex in Pattern Hair Loss and Telogen Effluvium

research Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms Behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin with Marilex in Pattern Hair Loss and Telogen Effluvium

10 citations, May 2020 in “Dermatology Research and Practice”

Proteoglycans are important for hair growth, and a specific treatment can help reduce hair loss.

research Whole Exome Sequencing in Alopecia Areata Identifies Rare Variants in KRT82

9 citations, February 2022 in “Nature communications”

Rare changes in the KRT82 gene are linked to a higher risk of Alopecia Areata.