TLDR The research suggests that immune cells and a specific type of cell death called ferroptosis are involved in Frontal fibrosis alopecia.
The study on frontal fibrosing alopecia (FFA) identified 636 differentially expressed genes (DEGs) and highlighted the roles of immune response and lipid metabolism. Key findings include 19 ferroptosis-related genes (FRGs) and a diagnostic model based on four DE-FRGs (CYP4F8, GCLC, PARP14, PARP3) with high accuracy (AUC of 0.924). Immune infiltration analysis showed significant differences in immune cells, particularly CD8+ T cells and M1 macrophages, between FFA lesions and controls. The research, which analyzed 14 clinical samples and validated findings with 48 additional samples, suggests that immune cells and ferroptosis are involved in FFA pathogenesis and identifies potential biomarkers for diagnosis. Further experimental validation is needed.
19 citations
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July 2022 in “PNAS Nexus” Similar treatments might work for different types of scarring hair loss.
34 citations
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June 2020 in “British journal of dermatology/British journal of dermatology, Supplement” Frontal fibrosing alopecia is linked to increased immune system activity and reduced stem cells, suggesting early treatment targeting this pathway might prevent hair follicle damage.
115 citations
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March 2019 in “Nature Communications” Frontal fibrosing alopecia is linked to four genetic areas, especially the HLA-B*07:02 allele.
17 citations
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October 2017 in “Journal of Cutaneous Medicine and Surgery” No treatment has been proven to effectively stop hair loss or regrow hair in Frontal Fibrosing Alopecia, and more research is needed.
13 citations
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March 2017 in “PubMed” People with a common type of hair loss have higher stress levels in their body, and treatments that reduce this stress could help.
Protein profiling of forehead skin can help distinguish between frontal fibrosing alopecia and androgenetic alopecia.
1 citations
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December 2023 in “Biomolecules” Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.
80 citations
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April 2018 in “Trends in Molecular Medicine” Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.
March 2025 in “JEADV Clinical Practice” People with primary scarring alopecia have higher risks of other health issues like vitamin D deficiency and thyroid disease.
2 citations
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July 2022 in “Frontiers in Medicine” The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.
