Transcriptome Analysis of Frontal Fibrosing Alopecia Revealed Involvement of Immune Cells and Ferroptosis
February 2024
in “
Skin research and technology
”
TLDR The research suggests that immune cells and a specific type of cell death called ferroptosis are involved in Frontal fibrosis alopecia.
The study on frontal fibrosing alopecia (FFA) identified 636 differentially expressed genes (DEGs) and highlighted the roles of immune response and lipid metabolism. Key findings include 19 ferroptosis-related genes (FRGs) and a diagnostic model based on four DE-FRGs (CYP4F8, GCLC, PARP14, PARP3) with high accuracy (AUC of 0.924). Immune infiltration analysis showed significant differences in immune cells, particularly CD8+ T cells and M1 macrophages, between FFA lesions and controls. The research, which analyzed 14 clinical samples and validated findings with 48 additional samples, suggests that immune cells and ferroptosis are involved in FFA pathogenesis and identifies potential biomarkers for diagnosis. Further experimental validation is needed.
