This study found that the proteins Par3, mInsc, and Gαi3 cooperate to regulate LGN polarization and promote perpendicular cell divisions during murine epidermal morphogenesis.
June 2026 in “International Journal of Pharmaceutical Sciences Review and Research” In this case report, Siddha therapies, including internal and external treatments, effectively reduced patchy hair loss and improved psychological well-being in a 23-year-old male with alopecia areata, without adverse effects; however, further studies are needed to confirm these findings.
26 citations
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July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, loss of epidermal Par3 in mice disrupted the skin barrier and affected cell differentiation and stem cell maintenance, highlighting its role in epidermal homeostasis.
March 2026 in “Journal of Enzyme Inhibition and Medicinal Chemistry” This review examines the development and challenges of using PROTACs, a targeted protein degradation strategy, to treat cancer by degrading specific proteins like PARPs and GPX4, highlighting issues such as target diversification and bioavailability.
February 2024 in “Skin research and technology” The researchers in this study identified molecular mechanisms involved in frontal fibrosis alopecia, highlighting immune response and fatty acid metabolism, and developed a four-gene diagnostic model showing high accuracy in distinguishing affected individuals from controls.