Comorbidities of Primary Scarring Alopecias: A Retrospective Multi-Site Cross-Sectional Study

In this case series, low-dose oral metformin was associated with improvements in symptoms and gene expression changes in Black female patients with treatment-resistant central centrifugal cicatricial alopecia, suggesting a potential therapeutic role for metformin in managing this condition.

In this study, researchers identified significant differences in protein expression patterns in scalps affected by central centrifugal cicatricial alopecia, notably upregulation of immune pathways and fibrosis markers and downregulation of metabolic proteins, suggesting unique disease mechanisms and potential therapeutic targets.

In this study, CCCA patients were found to have higher odds of metabolic, autoimmune, atopic, and psychiatric comorbidities compared to matched controls.

People with primary cicatricial alopecia have a higher risk of heart disease and stroke.

This study suggests that although data on JAK inhibitors for treating LPP and FFA is mainly from retrospective studies and case reports, these inhibitors may offer a new treatment option, particularly for challenging cases.

This article emphasizes the importance of educating dermatologists to reduce diagnostic delays in FD and highlights the need to screen for comorbid hidradenitis suppurativa and obtain bacterial cultures for effective treatment planning.

This study found mixed evidence linking traction hairstyles, previous pregnancies, chemical hair relaxers, and several comorbidities to an increased risk of central centrifugal cicatricial alopecia in Black women.

This review discusses the unclear etiology and potential contributing factors of frontal fibrosing alopecia and reports no new clinical findings.

This review discusses the potential role of a PADI3 gene variant in central centrifugal cicatricial alopecia among African-American women but reports no new clinical results.

This study found that clinical characteristics, concurrent medical conditions, and hair care practices may affect treatment outcomes in patients with central centrifugal cicatricial alopecia.

This review discusses central centrifugal cicatricial alopecia in adolescents, noting varied presentation and highlighting genetic and environmental factors, but reports no new clinical findings.

This article highlights a lack of published data on vitamin D deficiency prevalence among individuals with central centrifugal cicatricial alopecia, despite its known link to other forms of hair loss.

This review discusses hairstyling trends and health risks among Black women, noting that natural styles have the fewest adverse associations, though challenges remain in society's acceptance.

This meta-analysis found that patients with androgenetic alopecia had a significantly higher prevalence of metabolic syndrome and poorer metabolic profiles compared to controls, especially among females, those with early onset, and individuals of African ethnicity.

This study found no significant gene expression differences in the lesional scalp of patients with central centrifugal cicatricial alopecia with and without a history of uterine leiomyomas.

Patients with central centrifugal cicatricial alopecia may have a higher risk of breast and colorectal cancer.

Women with lichen planopilaris and frontal fibrosing alopecia often have other health issues like hypothyroidism and lupus.

In this study, women with lichen planopilaris were found to have high rates of thyroid disease, depression, and anxiety, and about half experienced slowed or stabilized disease progression with treatment.

In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.

This article discusses the staging of central centrifugal cicatricial alopecia in women of African descent and reports no new clinical results.

This review discusses the links between metabolic syndrome and various skin diseases, exploring shared mechanisms such as insulin resistance and inflammation, but reports no new clinical results.

This study found that type 2 diabetes was associated with a higher risk of severe central scalp hair loss in African American women.

In this study, patients with lichen planopilaris showed higher prevalence of autoimmune disorders like Hashimoto's thyroiditis and hypothyroidism compared to those with seborrheic dermatitis.

This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.

This study found that female patients with frontal fibrosing alopecia are significantly more likely to have systemic lupus erythematosus compared to controls.

This review discusses the roles of interferon-γ and PPAR-γ-mediated signalling in scarring alopecia, suggesting these pathways as potential therapeutic targets, but it reports no new empirical results.

This study found that patients with a greater awareness and understanding of androgenetic alopecia were more likely to seek treatment, suggesting that education may increase treatment willingness.

This study found that patients with androgenetic alopecia had a higher prevalence of metabolic syndrome compared to healthy controls.

This research analyzed 72 primary scarring alopecia cases in a Barcelona hospital, finding that the majority involved women, with a lymphocytic infiltrate and subacute onset in many cases, leading to stable disease, while neutrophilic cases had more acute episodes.

This study found that men with early-onset androgenic alopecia had a higher prevalence of metabolic syndrome compared to controls without the condition.

This study found a high prevalence of central hair loss among African American women and associated it with diabetes mellitus type 2, bacterial scalp infections, and hairstyles causing traction.

This study reviewed the epidemiology and treatment of inflammatory cicatricial alopecias and highlighted the importance of scalp biopsies for accurate diagnosis in a mixed ethnic population at a university hair clinic.