Central Centrifugal Cicatricial Alopecia Amalgamated with Alopecia Areata: Immunologic Findings

The document described a unique case of a 36-year-old African American female with a rare combination of central centrifugal cicatricial alopecia (CCCA) and alopecia areata (AA), exhibiting both scarring and non-scarring hair loss. Biopsies analyzed through various methods revealed diminished hair follicles, sebaceous gland damage, and immunologic features such as positive staining for CD4, CD8, CD45, proteases, and protease inhibitors, as well as antibodies to micelles. The patient's condition improved with intralesional corticosteroid treatment. The findings suggest an overlap syndrome of CCCA and AA with a complex immunoreactivity pattern, but the significance of these findings is not fully understood, highlighting the need for further research.