Central Centrifugal Cicatricial Alopecia Amalgamated with Alopecia Areata: Immunologic Findings

July 2014 in “ Our Dermatology Online ”

Ana Maria Abreu Velez, Bruce R. Smoller, Michael S. Howard

central centrifugal cicatricial alopecia alopecia areata scarring hair loss non-scarring hair loss hair follicles sebaceous gland damage CD4 CD8 CD45 proteases protease inhibitors antibodies to micelles intralesional corticosteroid treatment CCCA AA steroids

TLDR The patient with both scarring and non-scarring hair loss showed complex immune reactions and improved with steroid treatment.

The document described a unique case of a 36-year-old African American female with a rare combination of central centrifugal cicatricial alopecia (CCCA) and alopecia areata (AA), exhibiting both scarring and non-scarring hair loss. Biopsies analyzed through various methods revealed diminished hair follicles, sebaceous gland damage, and immunologic features such as positive staining for CD4, CD8, CD45, proteases, and protease inhibitors, as well as antibodies to micelles. The patient's condition improved with intralesional corticosteroid treatment. The findings suggest an overlap syndrome of CCCA and AA with a complex immunoreactivity pattern, but the significance of these findings is not fully understood, highlighting the need for further research.

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