Central Centrifugal Cicatricial Alopecia Amalgamated with Alopecia Areata: Immunologic Findings

July 2014 in “ Our Dermatology Online ”

Ana Maria Abreu Velez, Bruce R. Smoller, Michael S. Howard

central centrifugal cicatricial alopecia alopecia areata scarring hair loss non-scarring hair loss hair follicles sebaceous gland damage CD4 CD8 CD45 proteases protease inhibitors antibodies to micelles intralesional corticosteroid treatment CCCA AA steroids

TLDR The patient with both scarring and non-scarring hair loss showed complex immune reactions and improved with steroid treatment.

The document described a unique case of a 36-year-old African American female with a rare combination of central centrifugal cicatricial alopecia (CCCA) and alopecia areata (AA), exhibiting both scarring and non-scarring hair loss. Biopsies analyzed through various methods revealed diminished hair follicles, sebaceous gland damage, and immunologic features such as positive staining for CD4, CD8, CD45, proteases, and protease inhibitors, as well as antibodies to micelles. The patient's condition improved with intralesional corticosteroid treatment. The findings suggest an overlap syndrome of CCCA and AA with a complex immunoreactivity pattern, but the significance of these findings is not fully understood, highlighting the need for further research.

View this study on odermatol.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 55 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

in Treatment 4 upvotes 5 years ago

Derma rolling, pumpkin seed oil, and daily massages helped regrow weak hairs on the crown. Nizoral shampoo and yoga also contributed to reducing scalp pain and stress.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 90 upvotes 3 months ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community Exploring Bryan Johnson's Hair Routine In Detail

in Research/Science 65 upvotes 10 months ago

Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

Related Research

3 / 3 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.

research Oral Tofacitinib: A Promising Treatment in Atopic Dermatitis, Alopecia Areata, and Vitiligo

37 citations, October 2017 in “Clinical and Experimental Dermatology”

Oral tofacitinib shows promise in treating atopic dermatitis and alopecia areata, but only slight improvement in vitiligo.

research Vitiligo After Diphencyprone for Alopecia Areata

18 citations, January 2010 in “Dermatology Research and Practice”

DPCP treatment for alopecia areata can sometimes cause vitiligo.