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GlossaryCD4

protein on immune cells crucial for signaling and HIV entry

CD4 is a type of protein found on the surface of certain immune cells, such as T-helper cells. These cells play a crucial role in the immune system by signaling other cells to perform their functions. CD4 is also the primary receptor that HIV uses to enter and infect these immune cells, which can lead to a weakened immune system.

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research Skin CD4+ Memory T Cells Exhibit Combined Cluster-Mediated Retention and Equilibration with the Circulation

155 citations, May 2016 in “Nature communications”

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

research Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism

135 citations, December 2006 in “PLoS Medicine”

Hyaluronate fragments can help reverse skin thinning by working with the CD44 receptor.

research The Human Hair Follicle: A Reservoir of CD40+ B7-Deficient Langerhans Cells That Repopulate Epidermis After UVB Exposure

99 citations, April 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicles help skin immune recovery after UVB exposure.

CD4+CD25+FoxP3+ Regulatory Tregs Inhibit Fibrocyte Recruitment and Fibrosis via Suppression of FGF-9 Production in the TGF-β1 Exposed Murine Lung

research CD4+CD25+FoxP3+ Regulatory Tregs Inhibit Fibrocyte Recruitment and Fibrosis via Suppression of FGF-9 Production in the TGF-β1 Exposed Murine Lung

39 citations, May 2014 in “Frontiers in Pharmacology”

Special immune cells called Tregs can help prevent lung scarring by blocking a specific growth factor.

research The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability

28 citations, January 2013 in “Stem cells”

Certain human skin cells marked by CD44 and ALDH are rich in stem cells capable of long-term skin renewal.

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