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    Glossary CD4

    protein on immune cells crucial for signaling and HIV entry

    CD4 is a type of protein found on the surface of certain immune cells, such as T-helper cells. These cells play a crucial role in the immune system by signaling other cells to perform their functions. CD4 is also the primary receptor that HIV uses to enter and infect these immune cells, which can lead to a weakened immune system.

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    1. Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation Nature communications · 2016 · 155 citations
    2. Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism PLoS Medicine · 2006 · 135 citations
    3. The Human Hair Follicle: A Reservoir of CD40+ B7-Deficient Langerhans Cells that Repopulate Epidermis After UVB Exposure 1998 · 99 citations
    4. Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata Journal of Investigative Dermatology · 2002 · 77 citations
    5. PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus Rheumatology · 2019 · 71 citations
    6. CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung Frontiers in Pharmacology · 2014 · 39 citations
    7. <i>In vivo </i>CD44‐CD49d complex formation in autoimmune disease has consequences on T cell activation and apoptosis resistance European Journal of Immunology · 2006 · 33 citations
    8. Anti-CD44-mediated blockade of leukocyte migration in skin-associated immune diseases Journal of Leukocyte Biology · 2007 · 30 citations
    9. The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability Stem cells · 2013 · 28 citations
    10. Diphencyprone and topical tacrolimus as two topical immunotherapeutic modalities. Are they effective in the treatment of alopecia areata among Egyptian patients? A study using CD4, CD8 and MHC II as markers Journal of dermatological treatment · 2010 · 13 citations
    11. Spectrum of mucocutaneous manifestations in human immunodeficiency virus-infected patients and its correlation with CD4 lymphocyte count International Journal of STD & AIDS · 2014 · 12 citations
    12. DMBA/TPA Treatment Is Necessary for BCC Formation from Patched Deficient Epidermal Cells in Ptch flox/flox CD4Cre +/− Mice Journal of Investigative Dermatology · 2014 · 11 citations
    13. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance 2019 · 11 citations
    14. Letters: CD4+ Lymphocytopenia in Systemic Lupus Erythematosus Annals of Internal Medicine · 1994 · 10 citations
    15. Hyaluronate Accumulation and Decreased CD44 Expression in Perifollicular Solitary Cutaneous Myxoma Dermatology · 2002 · 9 citations
    16. CD44 signaling in skin wound healing and regeneration Journal of Translational Medicine · 2025 · 8 citations
    17. Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts Scientifica · 2020 · 7 citations
    18. CD80CD86 deficiency disrupts regulatory CD4+FoxP3+T cell homoeostasis and induces autoimmune-like alopecia Experimental dermatology · 2017 · 6 citations
    19. CUTANEOUS MANIFESTATIONS OF HIV-INFECTION IN RELATION WITH CD4 CELL COUNTS IN HADOTI REGION Journal of Evolution of Medical and Dental Sciences · 2013 · 6 citations
    20. CD44 expression in alopecia areata and androgenetic alopecia Journal of Cutaneous Pathology · 1994 · 5 citations
    21. Predominance of CD27-PD-1- Effector Memory T Cells Re-Expressing CD45RA Characterizes Treatment-Resistant Severe Alopecia Areata Journal of Investigative Dermatology · 2025 · 2 citations
    22. CD4 expression controls epidermal stem cell balance Scientific Reports · 2025 · 1 citations
    23. CD4 T cells from mice with alopecia areata express an effector like phenotype and can transfer disease The Journal of Immunology · 2023 · 1 citations
    24. Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1 Frontiers in Pharmacology · 2022 · 1 citations
    25. Characterisation of CD4+ stem cells of the skin and their role in skin homeostasis and tumourigenesis 2021 · 1 citations
    26. LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis Journal of Investigative Dermatology · 2024 · 1 citations
    27. In vitro analyses of CD4-protein function in dedifferentiated keratinocyte cell lines 2023
    28. Evaluation of CD4+, CD39+, FOXP3+Tregulatory cells in Iraqi Alopecia areata patients by ELISA Journal of pharmaceutical negative results · 2022
    29. 054 Deep Analysis of CD4+ Trm Cells in Normal and Atopic Dermatitis Human Skin Journal of Investigative Dermatology · 2025
    30. Mendelian Randomization Identifies CD25+ CD4+ Tregs and Plasma Proteins in Androgenetic Alopecia Pathogenesis DOAJ (DOAJ: Directory of Open Access Journals) · 2025