Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation

    January 2024 in “ JID Innovations ”
    Aditi Gadre, Taylor Dyson, Jaroslaw Jedrych … Crystal Aguh
    Studysummary In this study, researchers identified significant differences in protein expression patterns in scalps affected by central centrifugal cicatricial alopecia, notably upregulation of immune pathways and fibrosis markers and downregulation of metabolic proteins, suggesting unique disease mechanisms and potential therapeutic targets.
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    Research cited in this study 8

    1. Hair Regrowth in Two Patients with Recalcitrant Central Centrifugal Cicatricial Alopecia After Use of Topical Metformin JAAD Case Reports · 2020
    2. Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia The American Journal of Dermatopathology · 2018
    3. Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia PloS one · 2018
    4. Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia Journal of The American Academy of Dermatology · 2018
    5. Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia? Journal of Investigative Dermatology · 2016
    6. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    7. Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia PLOS ONE · 2012
    8. Normal Fur Development and Sebum Production Depend on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands Journal of biological chemistry/˜The œJournal of biological chemistry · 2011