TLDR CCCA involves immune response and metabolism issues, suggesting new treatment options.
This study on central centrifugal cicatricial alopecia (CCCA) used proteomic profiling to identify protein expression patterns, revealing 148 differentially expressed proteins in affected scalps. The findings highlighted upregulation of adaptive immune pathways, particularly involving IgG, and markers of fibrosis, alongside downregulation of metabolic proteins linked to lipid metabolism. These results suggest that CCCA involves unique mechanisms, including humoral immune responses and metabolic dysregulation, which could inform potential therapeutic strategies.
24 citations
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January 2020 in “JAAD Case Reports” Topical metformin helped regrow hair in two women with a hard-to-treat scarring hair loss condition.
6 citations
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December 2018 in “The American Journal of Dermatopathology” Early shedding of the inner root sheath in noninflamed hair follicles is a relatively specific sign of Central Centrifugal Cicatricial Alopecia.
14 citations
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October 2018 in “PloS one” Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.
25 citations
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June 2018 in “Journal of The American Academy of Dermatology” Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.
220 citations
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June 2013 in “The Journal of Pathology” Lichen planopilaris may be an autoimmune disease causing hair loss due to immune system issues in hair follicles.
22 citations
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June 2012 in “PLOS ONE” Cholesterol-related compounds can stop hair growth and cause inflammation in a type of scarring hair loss.
40 citations
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June 2011 in “Journal of biological chemistry/The Journal of biological chemistry” FA2H is essential for normal fur and sebum production in mice.
