Quantification of Mast Cells in Central Centrifugal Cicatricial Alopecia
December 2023
in “
JAAD International
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Research cited in this study
13 / 13 resultsresearch Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases
Mast cells and CD8 T cells interact closely in skin diseases, affecting each other's behavior and contributing to conditions like psoriasis and eczema.
research Primary Cicatricial Alopecias Are Characterized by Dysregulation of Shared Gene Expression Pathways
Similar treatments might work for different types of scarring hair loss.
research Gene expression profiling suggests severe, extensive central centrifugal cicatricial alopecia may be both clinically and biologically distinct from limited disease subtypes
This study on central centrifugal cicatricial alopecia (CCCA) suggested that severe, extensive CCCA might be both clinically and biologically distinct from limited disease subtypes. By analyzing tissue samples from women with varying degrees of CCCA, researchers found that severe cases showed increased expression of genes MMP9, SFRP4, and MSR1, which are associated with fibrosis, Wnt signaling, and macrophage-mediated inflammation. These findings indicated that severe CCCA could have a unique gene expression profile, offering potential targets for future research on prognostic markers and therapeutic interventions.
research Infiltration of Mast Cells in Scalp Biopsies of Patients with Alopecia Areata or Androgenic Alopecia Versus Healthy Individuals: A Case-Control Study
Alopecia patients have more mast cells in their scalps, especially in severe cases and older age, with alopecia areata showing the highest increase.
research Infiltration of Mast Cells in Scalp Biopsies of Patients with Alopecia Areata or Androgenic Alopecia Versus Healthy Individuals: A Case-Control Study
People with Alopecia Areata and Androgenic Alopecia have more mast cells in their scalp than healthy individuals, especially those with Alopecia Areata.
research Variant PADI3 in Central Centrifugal Cicatricial Alopecia
Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.
research Presence of Mast Cells and Mast Cell Degranulation in Scalp Biopsies of Telogen Effluvium
The study suggests that mast cells might be involved in the hair loss condition telogen effluvium and could be a target for treatment.
research Mast Cells and Scarring Alopecia: Is There a Clear Pathophysiological Relationship?
The document suggests a possible link between mast cells and scarring alopecia, recommending more research for potential treatments.
research Pathologic Diagnosis of Central Centrifugal Cicatricial Alopecia on Horizontal Sections
Horizontal sections of scalp biopsies are good for diagnosing Central Centrifugal Cicatricial Alopecia and help customize treatment.
research Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia
Type 2 diabetes, bacterial scalp infections, and tight hairstyles like braids and weaves are linked to a higher risk of a scarring hair loss condition in African American women.
research Therapeutic Hotline: Effectiveness of the Association of Cetirizine and Topical Steroids in Lichen Planus Pilaris - An Open-Label Clinical Trial
Combining cetirizine and topical steroids can effectively manage severe lichen planus pilaris.
research Central Scalp Alopecia Photographic Scale in African American Women
A scale was made to measure hair loss severity in African American women.
research An Atlas of Hair Pathology with Clinical Correlations
The book is a detailed guide on hair and scalp diseases, useful for dermatopathologists.