Infiltration of Mast Cells in Scalp Biopsies of Patients with Alopecia Areata or Androgenic Alopecia Versus Healthy Individuals: A Case-Control Study

    December 2020 in “ Galen Medical Journal ”
    Soheila Nasiri, Alireza Salehi, Azadeh Rakhshan
    Studysummary This study observed that patients with alopecia areata and androgenic alopecia have significantly more perifollicular and perivascular mast cells compared to healthy individuals, particularly in those over 40 and with greater disease severity.
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    Research cited in this study 8

    1. Androgenetic Alopecia: A Review Endocrine · 2017
    2. Presence of Mast Cells and Mast Cell Degranulation in Scalp Biopsies of Telogen Effluvium International Journal of Trichology · 2017
    3. Epidemiology and Burden of Alopecia Areata: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2015
    4. Early Stage Alopecia Areata Is Associated With Inflammation in the Upper Dermis and Damage to the Hair Follicle Infundibulum Australasian Journal of Dermatology · 2013
    5. Histologic Features of Alopecia Areata Other Than Peribulbar Lymphocytic Infiltrates 2011
    6. Androgenetic Alopecia in Males: A Histopathological and Ultrastructural Study Journal of Cosmetic Dermatology · 2009
    7. Alopecia in the United States: Outpatient Utilization and Common Prescribing Patterns Journal of the American Academy of Dermatology · 2007
    8. A Simple Immunofluorescence Technique for Simultaneous Visualization of Mast Cells and Nerve Fibers Reveals Selectivity and Hair Cycle-Dependent Changes in Mast Cell-Nerve Fiber Contacts in Murine Skin Archives of Dermatological Research · 1997