Infiltration of Mast Cells in Scalp Biopsies of Patients with Alopecia Areata or Androgenic Alopecia Versus Healthy Individuals: A Case-Control Study

December 2020 in “ Galen Medical Journal ”

Soheila Nasiri, Alireza Salehi, Azadeh Rakhshan

alopecia areata androgenic alopecia mast cells scalp biopsies perifollicular perivascular AA AGA

TLDR People with Alopecia Areata and Androgenic Alopecia have more mast cells in their scalp than healthy individuals, especially those with Alopecia Areata.

In a study conducted by Soheila Nasiri, Alireza Salehi, and Azadeh Rakhshan in 2020, they examined the presence of mast cells in scalp biopsies of patients with Alopecia Areata (AA) and Androgenic Alopecia (AGA) compared to healthy individuals. The study involved 60 subjects divided into three groups: AA, AGA, and a healthy control group, each consisting of 20 subjects. The results showed significantly higher perifollicular and perivascular mast cell counts in both AGA and AA groups compared to the healthy control group. Furthermore, AA patients had more frequent perivascular mast cells than the AGA group. The study also found that the increase in mast cell counts was age and severity dependent. In conclusion, the study found a significant increase in mast cell infiltration in AA and AGA patients, with the increase being more dominant in AA patients.

View this study on journals.salviapub.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community I’m 14 years old and I’m losing more hair than my dad. I’ve gone to the doctor 2 times because of this and I’ve received no help. I’m starting to feel like It’s worthless and my hairs gonna look like this forever. I don’t know how anyone could help me but it’s always worth a shot.

in Treatment 4 years ago

A 14 year old who is experiencing hair loss and has not received any help from the doctor, with advice being given to try different doctors, get tested for underlying conditions and intolerances, buzz it short as an option and treatments that could slow down or reverse the hair loss such as minoxidil, finasteride, RU58841 and addressing the cause of the hair loss.

community A hill on which I will die: The DHT itch absolutely exists

in Research/Science 211 upvotes 6 months ago

The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

community Is it ok to take Xeljanz (A jak inhibitor) while taking finasteride?

in Finasteride 2 upvotes 7 years ago

The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hair loss. The concern is that Xeljanz weakens the immune system, which could be risky.

community Olumiant active ingredient Baricitinib

in Research/Science 1 upvotes 1 year ago

The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

community Apparently onion juice promotes hair growth. I was very skeptical at first but there seem to be a lot of people commenting on this article that have had positive results

14 upvotes 10 years ago

Onion juice is discussed as a potential treatment for hair growth, with many positive user comments. Other treatments mentioned include Minoxidil, finasteride, and RU58841.

community Should I get transplant #4 or just shave my head?

in Transplants 169 upvotes 3 months ago

A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

Related Research

1 / 1 results

research Serum Zinc Concentration in Patients With Alopecia Areata

October 2023 in “Acta dermato-venereologica (Print)”

People with severe hair loss have lower zinc levels in their blood.