Central Centrifugal Cicatricial Alopecia Gene Expression Analysis Revealed Cholesterol, Fatty Acid, and Mast Cell Pathways

    April 2019 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    E. Wang, B. Sallee, J.C. Chen, Lisa M. Herron, Lindsey Bordone, A.M. Christiano
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    TLDR Targeting cholesterol, fatty acids, fibrosis, and mast cells may help treat CCCA.
    Central centrifugal cicatricial alopecia (CCCA) is a scarring hair loss condition primarily affecting women of African descent, with an estimated prevalence of 6-8%. RNAseq analysis of scalp biopsies from 5 CCCA patients revealed three key pathways: downregulation of steroid/cholesterol/fatty acid pathways, upregulation of fibrosis and hypertrophic scarring pathways, and upregulation of a mast cell signature. Histological analysis confirmed mast cell infiltration around fibrotic tissue. Current treatments are not effective, aligning with the lack of immune pathway dysregulation. The study suggested that therapies targeting cholesterol and fatty acid metabolism, fibrosis, and mast cells could improve clinical outcomes for CCCA and other cicatricial alopecias.
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