Central Centrifugal Cicatricial Alopecia Gene Expression Analysis Revealed Cholesterol, Fatty Acid, and Mast Cell Pathways

    April 2019 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    E. Wang, B. Sallee, J.C. Chen, Lisa M. Herron, Lindsey Bordone, A.M. Christiano
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    TLDR Targeting cholesterol, fatty acids, fibrosis, and mast cells may help treat CCCA.
    Central centrifugal cicatricial alopecia (CCCA) is a scarring hair loss condition primarily affecting women of African descent, with an estimated prevalence of 6-8%. RNAseq analysis of scalp biopsies from 5 CCCA patients revealed three key pathways: downregulation of steroid/cholesterol/fatty acid pathways, upregulation of fibrosis and hypertrophic scarring pathways, and upregulation of a mast cell signature. Histological analysis confirmed mast cell infiltration around fibrotic tissue. Current treatments are not effective, aligning with the lack of immune pathway dysregulation. The study suggested that therapies targeting cholesterol and fatty acid metabolism, fibrosis, and mast cells could improve clinical outcomes for CCCA and other cicatricial alopecias.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 3 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

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