Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases

    January 2023 in “ International journal of molecular sciences ”
    Yiqiao Chen, C.E.M. Griffiths, Silvia Bulfone–Paus∥
    TLDR Mast cells and CD8 T cells interact closely in skin diseases, affecting each other's behavior and contributing to conditions like psoriasis and eczema.
    The review explores the interactions between mast cells (MCs) and CD8 T cells in inflammatory skin diseases such as psoriasis, atopic dermatitis, vitiligo, and alopecia areata. It highlights the bidirectional communication between these cells through direct contact and soluble mediators, influencing each other's activities and contributing to disease pathogenesis and recurrence. Key molecular mechanisms include the formation of an immunological synapse (IS), costimulatory molecules like CD28-CD80/86 and OX40-OX40L, and chemokine signaling pathways such as CCL5-CCR5 and CXCL9/10/11-CXCR3. Understanding these interactions could lead to novel therapeutic strategies for managing these conditions.
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