Understanding Autoimmunity of Vitiligo and Alopecia Areata

    May 2016 in “ Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics ”
    Jillian F. Rork, Mehdi Rashighi, John E. Harris
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    TLDR Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.
    The article from August 2016 reviewed the autoimmune mechanisms shared between vitiligo and alopecia areata, highlighting the role of increased reactive oxygen species and cellular stress in triggering the innate immune response in both conditions. Genome-wide association studies have shown risk alleles affecting both innate and adaptive immunity. Crucially, research, particularly in mouse models, has identified an interferon (IFN)γ-driven immune response, including IFNγ itself, IFNγ-induced chemokines, and cytotoxic CD8 T cells as central to the pathogenesis of both diseases. These findings have led to the exploration of new treatment strategies targeting these pathways, with some early clinical studies showing promise and supporting the need for larger clinical trials.
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