Using Disease Symptomatology to Guide Treatment in Patients With Central Centrifugal Cicatricial Alopecia: Introduction of C-CAT Scoring Tool
September 2024
Research cited in this study
6 / 6 resultsresearch Beyond The Hot Comb: Updates In Epidemiology, Pathogenesis, And Treatment Of Central Centrifugal Cicatricial Alopecia From 2011 To 2021
research Gene expression profiling suggests severe, extensive central centrifugal cicatricial alopecia may be both clinically and biologically distinct from limited disease subtypes
This study on central centrifugal cicatricial alopecia (CCCA) suggested that severe, extensive CCCA might be both clinically and biologically distinct from limited disease subtypes. By analyzing tissue samples from women with varying degrees of CCCA, researchers found that severe cases showed increased expression of genes MMP9, SFRP4, and MSR1, which are associated with fibrosis, Wnt signaling, and macrophage-mediated inflammation. These findings indicated that severe CCCA could have a unique gene expression profile, offering potential targets for future research on prognostic markers and therapeutic interventions.
research The Efficacy of Antimalarial Drugs in the Therapy of Selected Forms of Cicatricial Alopecia
Hydroxychloroquine can help treat certain types of hair loss.
research Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety
Oral minoxidil promotes hair growth but may cause side effects; needs monitoring.
research Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia
Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.
research Central Centrifugal Cicatricial Alopecia: Challenges and Solutions
The document concludes that better treatments for CCCA are needed and more research is required to understand its causes related to hairstyling and genetics.