Gene Expression Profiling Suggests Severe, Extensive Central Centrifugal Cicatricial Alopecia May Be Both Clinically and Biologically Distinct From Limited Disease Subtypes

    January 2022 in “ Experimental Dermatology ”
    Taylor A. Jamerson, C. Conover Talbot, Yemisi Dina … Crystal Aguh
    Studysummary This study suggests that patients with severe, extensive central centrifugal cicatricial alopecia may exhibit a distinct gene expression pattern in the lesional scalp, highlighting potential targets for future research on disease severity and therapies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on hdl.handle.net →
    Discuss this study in the Community →

    Research cited in this study 7

    1. Dermatoscopic Evaluation of Central Centrifugal Cicatricial Alopecia Beyond the Vertex Scalp JAMA dermatology · 2020
    2. Variant PADI3 in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019
    3. Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia Journal of The American Academy of Dermatology · 2018
    4. Updates in the Understanding and Treatments of Skin and Hair Disorders in Women of Color International Journal of Women’s Dermatology · 2017
    5. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016
    6. Central Scalp Alopecia Photographic Scale in African American Women Dermatologic Therapy · 2008
    7. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007