Immunologic Findings in Central Centrifugal Cicatricial Alopecia

The study evaluated a 46-year-old African American female with central centrifugal cicatricial alopecia (CCCA) and found that premature desquamation of the inner root sheath and eccentric thinning of the follicular epithelium were key histopathologic features. Immunologic analysis revealed strong depositions of IgG, Complement/C3, and fibrinogen around hair follicles and supply vessels, along with increased expressions of VEGF and Oct-4. These findings suggested that the etiology of CCCA might involve not only hair traction but also a reactive immune response.