Immunologic Findings in Central Centrifugal Cicatricial Alopecia

July 2012 in “ Nasza Dermatologia Online ”

Ana Maria Abreu Velez, Alfred Klein, Michael S. Howard

central centrifugal cicatricial alopecia inner root sheath follicular epithelium IgG Complement/C3 fibrinogen hair follicles VEGF Oct-4 CCCA vascular endothelial growth factor

TLDR CCCA may be caused by both hair traction and an immune response.

The study evaluated a 46-year-old African American female with central centrifugal cicatricial alopecia (CCCA) and found that premature desquamation of the inner root sheath and eccentric thinning of the follicular epithelium were key histopathologic features. Immunologic analysis revealed strong depositions of IgG, Complement/C3, and fibrinogen around hair follicles and supply vessels, along with increased expressions of VEGF and Oct-4. These findings suggested that the etiology of CCCA might involve not only hair traction but also a reactive immune response.

View this study on odermatol.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 68 results

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 7 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

in Treatment 4 upvotes 5 years ago

Derma rolling, pumpkin seed oil, and daily massages helped regrow weak hairs on the crown. Nizoral shampoo and yoga also contributed to reducing scalp pain and stress.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 86 upvotes 8 months ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community Exploring Bryan Johnson's Hair Routine In Detail

in Research/Science 63 upvotes 1 year ago

Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

Similar Research

5 / 1000+ results

research Black Women's Hair: The Main Scalp Dermatoses and Aesthetic Practices in Women of African Ethnicity

32 citations, August 2015 in “Anais Brasileiros de Dermatologia”

Black women's unique hair characteristics and styling practices can lead to specific scalp conditions, which require early diagnosis and appropriate treatment.

research Cicatricial (Scarring) Alopecias: Comprehensive Review and Management

44 citations, April 2012 in “American Journal of Clinical Dermatology”

Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.

research Histopathologic Evaluation of Alopecias

90 citations, June 2006 in “The American Journal of Dermatopathology”

The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.

research Hair and Scalp Disorders in Women of African Descent: An Overview

20 citations, October 2013 in “British Journal of Dermatology”

The document concludes that clinicians should be aware of common hair and scalp disorders in women of African descent and that more research is needed to develop effective treatments.

research A Histologic Review of 27 Patients with Lichen Planopilaris

76 citations, June 2008 in “Journal of the American Academy of Dermatology”

The conclusion is that certain scalp tissue changes are characteristic of lichen planopilaris, with mucinous perifollicular fibroplasia being a new feature for diagnosis.