Immunologic Findings in Central Centrifugal Cicatricial Alopecia

July 2012 in “ Nasza Dermatologia Online ”

Ana Maria Abreu Velez, Alfred Klein, Michael S. Howard

central centrifugal cicatricial alopecia inner root sheath follicular epithelium IgG Complement/C3 fibrinogen hair follicles VEGF Oct-4 CCCA vascular endothelial growth factor

TLDR CCCA may be caused by both hair traction and an immune response.

The study evaluated a 46-year-old African American female with central centrifugal cicatricial alopecia (CCCA) and found that premature desquamation of the inner root sheath and eccentric thinning of the follicular epithelium were key histopathologic features. Immunologic analysis revealed strong depositions of IgG, Complement/C3, and fibrinogen around hair follicles and supply vessels, along with increased expressions of VEGF and Oct-4. These findings suggested that the etiology of CCCA might involve not only hair traction but also a reactive immune response.

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