TLDR JAK inhibitors, like ruxolitinib, may effectively treat frontal fibrosing alopecia.
This document presents a case series involving 3 patients with refractory frontal fibrosing alopecia (FFA) treated with Janus kinase (JAK) inhibitors, specifically topical ruxolitinib and oral baricitinib. The study highlights significant clinical improvements, including reduced pruritus, perifollicular erythema, and scale, with some evidence of hair regrowth. The cases suggest that JAK inhibitors, particularly topical ruxolitinib, may be a promising treatment for FFA, potentially due to their ability to penetrate the thinner skin of the frontal scalp more effectively. The findings support the role of JAK1/JAK2 in the pathogenesis and treatment of FFA, although further research is needed to fully understand the mechanisms involved.
13 citations
,
April 2022 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” The document concludes that more research is needed to find effective treatments for Lichen planopilaris and Frontal fibrosing alopecia.
23 citations
,
April 2021 in “Journal of Clinical Medicine” Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.
34 citations
,
June 2020 in “British journal of dermatology/British journal of dermatology, Supplement” Frontal fibrosing alopecia is linked to increased immune system activity and reduced stem cells, suggesting early treatment targeting this pathway might prevent hair follicle damage.
9 citations
,
January 2020 in “Postepy Dermatologii I Alergologii” Frontal fibrosing alopecia is a poorly understood condition with increasing cases and unclear treatment effectiveness.
38 citations
,
January 2019 in “International Journal of Women's Dermatology” The document concluded that more research is needed to find the best treatment for Frontal fibrosing alopecia.
79 citations
,
September 2018 in “Dermatologic therapy” Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.
63 citations
,
July 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” JAK inhibitors can effectively reverse hair loss in people with alopecia areata.
