Central Centrifugal Cicatricial Alopecia in Adolescents: Overview of Literature

April 2023 in “ Life ”

Victoria Palmer, Manuel Valdebran

central centrifugal cicatricial alopecia scarring alopecia genetic factors environmental factors metabolic dysregulation diabetes breast cancer biopsy CCCA

Studysummary This review discusses central centrifugal cicatricial alopecia in adolescents, noting varied presentation and highlighting genetic and environmental factors, but reports no new clinical findings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Central Centrifugal Cicatricial Alopecia (CCCA) primarily affects women of African descent and is emerging in adolescents and Asian populations. The condition involves genetic and environmental factors, including hairstyling practices, and is linked to metabolic dysregulation, increasing risks for diabetes and breast cancer. A study of 6 adolescents with CCCA showed varied symptoms like scalp pruritus and patchy hair loss, suggesting an autosomal dominant inheritance pattern and dysregulated inflammatory pathways. Early diagnosis through biopsies is crucial. Management is challenging, requiring early intervention and therapies such as topical corticosteroids and behavioral modifications. The document emphasizes the need for further research to improve understanding and treatment strategies.

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research Beyond The Hot Comb: Updates In Epidemiology, Pathogenesis, And Treatment Of Central Centrifugal Cicatricial Alopecia From 2011 To 2021

16 citations , November 2022 in “American Journal of Clinical Dermatology”

research Gene Expression Profiling Suggests Severe, Extensive Central Centrifugal Cicatricial Alopecia May Be Both Clinically and Biologically Distinct From Limited Disease Subtypes

11 citations , January 2022 in “Experimental Dermatology”

This study suggests that patients with severe, extensive central centrifugal cicatricial alopecia may exhibit a distinct gene expression pattern in the lesional scalp, highlighting potential targets for future research on disease severity and therapies.

research Association of Breast and Colorectal Cancer in Patients With Central Centrifugal Cicatricial Alopecia: A Retrospective, Cross-Sectional Pilot Study

9 citations , October 2020 in “Journal of the American Academy of Dermatology”

Patients with central centrifugal cicatricial alopecia may have a higher risk of breast and colorectal cancer.

research Central Centrifugal Cicatricial Alopecia: Challenges and Solutions

37 citations , August 2016 in “Clinical, Cosmetic and Investigational Dermatology”

This article discusses central centrifugal cicatricial alopecia, highlighting its prevalence, potential genetic factors, and management challenges, but reports no new clinical conclusions and calls for further research.

research Factors Affecting the Severity of Central Centrifugal Cicatricial Alopecia

29 citations , January 2016 in “International Journal of Dermatology”

This study reports that the duration of hair loss is positively associated with the severity of central centrifugal cicatricial alopecia in African-American women.

research Alopecia: Children Are Not Just Little People

8 citations , September 2015 in “Clinics in Dermatology”

This article discusses how the diagnosis and management of alopecia differ significantly between adults and children, emphasizing age-specific approaches but reports no new clinical findings.

research Central Centrifugal Cicatricial Alopecia: Possible Familial Aetiology in Two African Families from South Africa

15 citations , November 2012 in “International Journal of Dermatology”

This case series observed a potential familial link in central centrifugal cicatricial alopecia (CCCA), suggesting a genetic predisposition that may be worsened by hair grooming practices.

research Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia

88 citations , April 2011 in “Archives of Dermatology”

This study found a high prevalence of central hair loss among African American women and associated it with diabetes mellitus type 2, bacterial scalp infections, and hairstyles causing traction.

research Central Hair Loss in African American Women: Incidence and Potential Risk Factors

76 citations , November 2010 in “Journal of The American Academy of Dermatology”

In this study, a photographic scale and questionnaire revealed that extensive central scalp hair loss was observed in 5.6% of African American women, with an association to a history of tinea capitis.

research Central Centrifugal Cicatricial Alopecia: Retrospective Chart Review

25 citations , September 2010 in “Journal of Cutaneous Medicine and Surgery”

This study found that central centrifugal cicatricial alopecia primarily affects adult women of African descent and suggests an association with traumatic hair care practices and delayed diagnosis.

research Central Centrifugal Cicatricial Alopecia

72 citations , July 2008 in “Dermatologic Therapy”

This article reviews central centrifugal cicatricial alopecia in African-descent females, discussing possible causes, associated styling habits, and potential treatments, but reports no new clinical findings; the authors call for further research.