Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis
February 2022
in “
Research Square (Research Square)
”
TLDR High TSPEAR levels in colorectal cancer predict worse outcomes.
The study found that TSPEAR gene expression is significantly higher in colorectal cancer (CRC) tissues and cell lines compared to normal colon cells. High TSPEAR expression is associated with poor overall prognosis, advanced disease stage (M1), elevated CEA levels, and residual tumors. Multivariate analysis confirmed TSPEAR as an independent risk factor for CRC patients. Gene function and pathway enrichment analyses suggested that TSPEAR may regulate the Wnt and Hippo signaling pathways and various cell metabolism activities. Additionally, TSPEAR expression is positively correlated with immune cell infiltration and diverse immune marker sets, particularly in COAD. These findings suggest that TSPEAR could be a valuable predictive biomarker for CRC and is associated with tumor-infiltrating immune cells.
