Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis

The study found that TSPEAR gene expression is significantly higher in colorectal cancer (CRC) tissues and cell lines compared to normal colon cells, and this increased expression is associated with poor overall prognosis. High TSPEAR levels correlate with advanced cancer stages, higher CEA levels, and residual tumors. Multivariate analysis confirmed TSPEAR as an independent risk factor for CRC. Gene function and pathway enrichment analyses suggest that TSPEAR may regulate the Wnt and Hippo signaling pathways and various cell metabolism activities. Additionally, TSPEAR expression is positively correlated with immune cell infiltration and diverse immune marker sets, particularly in COAD, indicating its potential as a predictive biomarker for CRC patients.