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In this study, cedrol was found to reduce lipid accumulation in the liver and adipose tissues of dexamethasone-treated mice by antagonizing glucocorticoid receptors, suggesting its potential utility in treating dexamethasone-induced lipid metabolism disorders.

This study found that both ethanol and aqueous extracts of Lepidium sativum seeds improved insulin signaling and reduced obesity-related metabolic changes in high-fat diet-fed rats, suggesting potential as a dietary supplement.

This study observed that female mice with disrupted 5α-reductase 1 showed increased insulin resistance and hepatic steatosis, suggesting altered glucocorticoid metabolism contributes to metabolic disorders.

This study found that fasting insulin levels are associated with increased cardiovascular and metabolic risk factors in women with polycystic ovary syndrome.

This review examines rodent models to explore how maternal conditions like undernutrition, obesity, hypoxia, and androgen exposure affect fetal programming and metabolic outcomes in offspring, but presents no new clinical findings.

This study found that maternal PPARγ is essential for preventing the production of inflammatory lipids in mouse milk, which can otherwise cause inflammation, alopecia, and growth retardation in nursing pups.

This study showed that regulation of adipose androgen generation via AKR1C3 may contribute to a cycle of hyperinsulinaemia and lipid accumulation in women with PCOS.

This study utilized a mouse model of traumatic brain injury to reveal that acute neurotrauma triggers widespread lipid metabolism reprogramming and storage lipid accumulation in microglial and monocyte populations, leading to lysosomal dysfunction, inhibited autophagy, and exacerbated inflammation through a pathological feedback loop.

In this rat study, offspring from females fertilized by finasteride-treated males showed hyperglycemia and increased hepatic glycogen, linking paternal androgen imbalance to liver issues across generations.

This article discusses the potential health risks associated with long-term use of finasteride and dutasteride for prostate and hair loss treatments, suggesting risks may include non-alcoholic fatty liver disease, insulin resistance, type 2 diabetes, and other metabolic issues.

This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.

This study found that hair follicle mesenchymal stem cells are similar to bone marrow stem cells in most characteristics, but differ in their adipogenic and osteogenic differentiation capabilities, suggesting they may be a suitable source for adipogenesis research.

This study found that lipid accumulation product (LAP) and free androgen index (FAI) can highly predict liver steatosis in women with PCOS phenotype A.

This study found that finasteride significantly improved motor, EEG, and cellular changes in a rat model of thioacetamide-induced hepatic encephalopathy and prevented the development of hepatic coma.

The researchers reported that PPARβ/δ may influence the yak hair follicle cycle by modulating lipid metabolism in dermal papilla cells, with varying expression during different hair growth phases, affecting both lipid content and cell proliferation.

This study investigated the effects of pathological α-synuclein on sebaceous gland cells in Parkinson's disease, finding that α-synuclein exposure altered cellular differentiation and lipid production, suggesting a potential link between α-synuclein and lipid dysregulation in the skin of PD patients.

This study investigated pyranoanthocyanin Vitisin A and found it significantly lowered triglyceride levels and reduced body weight in high-fat diet-fed mice, outperforming Cyanidin-3-O-glucoside by inhibiting hepatic lipogenesis and enhancing fatty acid β-oxidation.

This case report identifies an adolescent with symptoms indicative of Dunnigan-type partial lipodystrophy, emphasizing the need for early diagnosis to manage associated metabolic complications and improve self-esteem.

In this study, manipulation of the enzyme 5α-reductase type 2 in human hepatocytes altered lipogenesis, suggesting clinical implications for patients using 5α-reductase inhibitors by affecting glucocorticoid action on hepatic lipid metabolism.

This review explores the association between sleep disturbances, obstructive sleep apnoea, and metabolic consequences like Type 2 diabetes, but reports no new experimental results; the authors elaborate on existing knowledge and suggest complex interconnections with fat accumulation and various syndromes.

In this study, finasteride was found to reduce cholesterol levels and delay atherosclerosis in LDL receptor-deficient mice, and men using finasteride reported lower cholesterol levels, suggesting potential cardiovascular benefits by improving lipid profiles.

This study found that PRL-1-overexpressing PD-MSCs reduced adipogenesis in orbital fibroblasts from Graves' ophthalmopathy patients by secreting IGFBPs and modulating the FAK pathway.

In this study, the researchers found that glucocorticoid receptor activation may influence glucose metabolism, with preventive GR antagonist treatment reducing hyperglycemia and restoring glucose tolerance in a PCOS mouse model.

In this study, periodic exposure to red light in aged mice led to increased histone acetylation and activated mitochondrial fatty acid oxidation, which collectively mitigated cellular aging by modulating metabolism, inflammation, and gene expression.

This study found that placenta-derived mesenchymal stem cells overexpressing PRL-1 inhibited adipogenesis in orbital fibroblasts from Graves’ ophthalmopathy patients by modulating specific signaling pathways, suggesting a potential therapeutic strategy.

This study identified transcription elongation as a crucial regulatory factor in adipocyte cell fate, showing that the elongation factors Spt4 and Spt6 are essential for proper adipogenic differentiation by aiding RNA polymerase II progression through key adipogenic genes.

This review suggests that the TSC22D family genes may influence metabolism and cancer, potentially serving as a therapeutic target for conditions like diabetes, obesity, and certain tumors, depending on the tumor environment.

This study suggests that finasteride treatment in male rats can lead to changes in liver carbohydrate metabolism and may result in metabolic disruptions and liver steatosis in their offspring.

In this study, women with PCOS had a higher prevalence of hepatic steatosis compared to controls, with associated metabolic issues like insulin resistance and metabolic syndrome.

This study found that lipin 1β expression in both visceral and subcutaneous adipose tissue is significantly lower in PCOS patients compared to controls, suggesting its involvement in the pathogenesis of insulin resistance.