The Transcription Elongation Factors Spt4 and Spt6 Promote Dermal Adipocyte Differentiation

    March 2026 in “ Adipocyte ”
    Julian Gomez, Samiksha Mahapatra, Uyanga Batzorig … George L. Sen
    Studysummary This study identified transcription elongation as a crucial regulatory factor in adipocyte cell fate, showing that the elongation factors Spt4 and Spt6 are essential for proper adipogenic differentiation by aiding RNA polymerase II progression through key adipogenic genes.
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    Research cited in this study 4

    1. Nelfb Promotes Dermal White Adipose Tissue Formation Through RNA Polymerase II Mediated Adipogenic Gene Regulation Development · 2025
    2. ELL Facilitates RNA Polymerase II-Mediated Transcription of Human Epidermal Proliferation Genes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    3. Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing Development · 2013
    4. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011