Glucocorticoid Receptor Antagonism Improves Glucose Metabolism in a Mouse Model of Polycystic Ovary Syndrome

    December 2023 in “ Journal of the Endocrine Society ”
    Sheng Li, Zhixiong Ying, Max Gentenaar, Patrick C.N. Rensen, Sander Kooijman, Jenny A. Visser, Onno C. Meijer, Jan Kroon
    Image of study
    TLDR Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.
    In a study using a mouse model of polycystic ovary syndrome (PCOS) induced by chronic dihydrotestosterone (DHT) exposure, researchers found that glucocorticoid receptor (GR) signaling is upregulated in the liver and white adipose tissues. Preventive administration of a selective GR antagonist improved glucose metabolism by alleviating DHT-induced hyperglycemia and restoring glucose tolerance, although it did not significantly affect total fat mass or lipid accumulation. This suggests that GR activation may contribute to glucose metabolism issues in PCOS.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    5 / 5 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community NootBro Recommendations… How Do We Feel

      in Research/Science  10 upvotes 10 months ago
      The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.

      community We Need A Solution For The Inflammatory Response related To AGA

      in Research/Science  16 upvotes 7 months ago
      The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

      community AA and Hirsutism but T levels are normal

      in Female  6 upvotes 4 years ago
      27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

    Similar Research

    5 / 1000+ results