GLP-1 Receptor Analogs: Evidence Linking to Effect on Metabolic and Reproductive Functions in Patients with PCOS and Obesity

July 2025 in “ Obesity Facts ”

Özlem Çelik, Dilek Yazıcı, Andreea Ciudin, Djuro Macut, Dragan Micić, Volkan Yumuk, Bülent Okan Yıldız

TLDR GLP-1 receptor analogs may help improve metabolism and reproductive health in people with PCOS and obesity.

The review article examines the effects of GLP-1 receptor analogs on metabolic and reproductive functions in patients with PCOS and obesity. It highlights that these analogs, commonly used for type 2 diabetes, show promise in improving insulin sensitivity, promoting weight loss, and enhancing reproductive outcomes such as menstrual regularity and fertility. Combination therapies with metformin often yield superior results compared to monotherapies, with significant improvements in ovulation rates and metabolic parameters. However, the exact mechanisms and long-term effects of GLP-1 receptor analogs on ovarian function require further investigation. Overall, these analogs appear to be a beneficial therapeutic option for managing PCOS and obesity-related challenges.

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research Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

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Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

A 12-Week Treatment with the Long-Acting Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Leads to Significant Weight Loss in a Subset of Obese Women with Newly Diagnosed Polycystic Ovary Syndrome

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61 citations , January 2015 in “Hormones”

Liraglutide caused significant weight loss in some obese women with PCOS, especially those with severe obesity and insulin resistance.

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Combining liraglutide and metformin helps obese women with PCOS who didn't lose weight on metformin alone to lose more weight.

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