Effective Amelioration of Hepatic Inflammation and Insulin Response in High-Fat Diet-Fed Rats via Regulating AKT/mTOR Signaling: Role of Lepidium Sativum Seed Extracts
October 2020
in “
Journal of ethnopharmacology
”
Lepidium sativum insulin resistance inflammation high-fat diet liver enzymes lipid levels leptin oxidative stress antioxidant capacity insulin signaling phenolic components flavonoid components bioactive components anti-obesity anti-inflammatory antioxidant properties glucose levels body weight antioxidant enzymes insulin signaling pathways garden cress HFD antioxidants bioactives
TLDR Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.
In a study from February 1, 2021, researchers explored the effects of Lepidium sativum seed extracts on obesity-related insulin resistance and inflammation in rats fed a high-fat diet (HFD). The study involved obese rats treated with ethanol (LSEE) and aqueous (LSAE) extracts of Lepidium sativum at various doses for 8 weeks following 10 weeks of HFD. The results showed that HFD-fed rats experienced increased liver enzymes, lipid levels, leptin, oxidative stress, and decreased antioxidant capacity, along with impaired insulin signaling. Both LSEE and LSAE, which contain phenolic, flavonoid, and other bioactive components, demonstrated anti-obesity, anti-inflammatory, and antioxidant properties. They significantly reduced glucose, leptin, lipid levels, liver enzymes, and body weight, while also restoring antioxidant enzymes and enhancing insulin signaling pathways in the liver. This suggests that LSEE and LSAE could be effective dietary supplements for preventing metabolic alterations and weight gain induced by HFD, with the added benefit of activating the insulin signaling pathway and having low toxicity.
