Functionally Enhanced Placenta-Derived Mesenchymal Stem Cells Inhibit Adipogenesis in Orbital Fibroblasts With Graves’ Ophthalmopathy

    November 2020 in “ Stem Cell Research & Therapy ”
    Jae Yeon Kim, Sohae Park, Hyun-Jung Lee, Helen Lew, Gi Jin Kim
    TLDR Enhanced stem cells from the placenta can help treat Graves' eye disease by stopping fat cell growth.
    The study investigated the effects of PRL-1-overexpressing placenta-derived mesenchymal stem cells (PD-MSCs PRL-1) on adipogenesis in orbital fibroblasts (OFs) from patients with Graves’ ophthalmopathy (GO). The researchers found that PD-MSCs PRL-1 significantly reduced lipid accumulation and decreased the expression of adipogenic markers in OFs compared to naïve cells. This effect was mediated by the secretion of insulin-like growth factor-binding proteins (IGFBPs), which downregulated the PI3K/AKT/mTOR signaling pathway and upregulated phosphorylated FAK through integrin interactions. The study concluded that functionally enhanced PD-MSCs could offer a novel therapeutic strategy for treating degenerative diseases like GO by inhibiting adipogenesis.
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