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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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5 / 1000+ resultsresearch Functionally Enhanced Placenta-Derived Mesenchymal Stem Cells Inhibit Adipogenesis in Orbital Fibroblasts With Graves’ Ophthalmopathy
Enhanced stem cells from the placenta can help treat Graves' eye disease by stopping fat cell growth.
research Functionally Enhanced Placenta-Derived Mesenchymal Stem Cells Inhibit Adipogenesis in Orbital Fibroblasts With Graves’ Ophthalmopathy
Enhanced stem cells from the placenta can reduce fat buildup in eye tissue for Graves' disease.
research Functionally Enhanced Placenta-Derived Mesenchymal Stem Cells Inhibit Adipogenesis in Orbital Fibroblasts With Graves’ Ophthalmopathy
The study investigated the effects of PRL-1-overexpressing placenta-derived mesenchymal stem cells (PD-MSCs PRL-1) on adipogenesis in orbital fibroblasts (OFs) from patients with Graves’ ophthalmopathy (GO). The research found that PD-MSCs PRL-1 significantly reduced lipid accumulation and decreased the expression of adipogenic markers in OFs compared to naïve cells. This effect was linked to the secretion of insulin-like growth factor-binding proteins (IGFBPs) by PD-MSCs PRL-1, which downregulated the PI3K/AKT/mTOR signaling pathway and upregulated phosphorylated FAK through integrin interactions. These findings suggested that functionally enhanced PD-MSCs could offer a novel therapeutic approach for treating degenerative diseases like GO.
research Mechanisms of Hepatocyte Attachment to Keratin Biomaterials
Human liver cells stick to hair protein materials mainly through the liver's asialoglycoprotein receptor.
research In Vivo CD44-CD49d Complex Formation in Autoimmune Disease Has Consequences on T Cell Activation and Apoptosis Resistance
The CD44-CD49d complex boosts T cell activation and survival in autoimmune disease.
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