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330-360 / 652 resultsresearch Cell Surface B2m-Free Human Leukocyte Antigen (HLA) Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?
B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.
![Regulatory T cells in inflammatory skin disease: from mice to humans](/images/research/14ecc2db-1cdc-4261-8a79-7425a8e77faf/small/30859.jpg)
research Regulatory T cells in inflammatory skin disease: from mice to humans
Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.
![Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride](/images/research/fa3cdf0c-c7b7-4025-9d4e-121a4258f109/small/4968.jpg)
research Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.
![Obstetric Dermatology](/images/research/a9d5f98d-52ac-48b5-a29b-45467e3a82b7/small/24810.jpg)
research Obstetric Dermatology
The document concludes that managing skin conditions during pregnancy is important and requires specialized care.
![Cutaneous signals of immune system disease](/images/research/e3a426b7-ae75-49a2-8e95-e75e3955bc69/small/27680.jpg)
research Cutaneous signals of immune system disease
Skin issues can indicate immune system problems.
research Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity
Malt1 protease is essential for regulatory T cell function and could be targeted to boost antitumor immunity.
research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications
Alopecia areata severity and treatment response are linked to specific cytokine levels.
![The expanding impact of T-regs in the skin](/images/research/73598752-28f0-466d-8c23-d0ec4ba1f021/small/19171.jpg)
research The expanding impact of T-regs in the skin
T-regulatory cells are important for skin health and can affect hair growth and reduce skin inflammation.
![The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycaemia, Elevated Hepatic Glycogen Storage and Altered GLUT2, IR, and AR Expression in the Liver](/images/research/3a08e117-c1e9-4961-8cbd-e2e8f1752f34/small/5107.jpg)
research The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycaemia, Elevated Hepatic Glycogen Storage and Altered GLUT2, IR, and AR Expression in the Liver
Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.
![Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment](/images/research/7193bea5-ce64-4617-9e40-155db82d6d2f/small/5300.jpg)
research Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment
Microneedles help treat hair loss by improving hair surroundings and promoting growth.
![5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction](/images/research/7fe680ad-8571-46ae-ab7c-f81015026bd3/small/13478.jpg)
research 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction
Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.
![Antisense oligonucleotide targeting fibroblast growth factor receptor (FGFR)-1 stimulates cellular activity of hair follicles in an<i>in vitro</i>organ culture system](/images/research/b325709e-8786-4464-9634-c0c9f81e64f0/small/15177.jpg)
research Antisense oligonucleotide targeting fibroblast growth factor receptor (FGFR)-1 stimulates cellular activity of hair follicles in anin vitroorgan culture system
Targeting FGFR-1 with antisense oligonucleotides may help treat baldness by increasing hair follicle activity.
![Topical Calcipotriol versus oral vitamin D in the treatment of alopecia areata](/images/research/8af135e2-9682-46e4-bd7f-7b636e49e9db/small/30081.jpg)
research Topical Calcipotriol versus oral vitamin D in the treatment of alopecia areata
Rubbing calcipotriol on the skin works better than taking vitamin D pills for treating mild to moderate alopecia areata.
![Skin Commensal Antigens: Taking the Road Less Traveled](/images/research/1f1b9501-7bd0-4961-b78c-010c0c0e88d6/small/19460.jpg)
research Skin Commensal Antigens: Taking the Road Less Traveled
Skin bacteria can help wound healing by activating certain immune cells.
![EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes](/images/research/98529b0d-a470-41d0-b53d-a1080184eaa8/small/30755.jpg)
research EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes
EDA and EDAR are important for hair follicle development in cashmere goats and affect other related genes.
![Molecular Docking Studies and ADME Prediction of Novel Isatin Analogs with Potent Anti-EGFR Activity](/images/research/cc73c250-2dd0-4283-8ed6-4d7f5b73c1af/small/22650.jpg)
research Molecular Docking Studies and ADME Prediction of Novel Isatin Analogs with Potent Anti-EGFR Activity
Some new isatin compounds could be strong cancer-fighting drugs because they fit well in cancer-related proteins and have good drug-like properties.
![Identification of factors contributing to phenotypic divergence via quantitative image analyses of autosomal recessive woolly hair/hypotrichosis with homozygous c.736T>A<i><scp>LIPH</scp></i>mutation](/images/research/13d8883f-0b58-4519-9efb-79350bf6badf/small/32226.jpg)
research Identification of factors contributing to phenotypic divergence via quantitative image analyses of autosomal recessive woolly hair/hypotrichosis with homozygous c.736T>ALIPH mutation
Different hair fiber development might explain why hair loss severity varies in patients with a specific genetic mutation, and treatments that thicken hair could help.
![Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs](/images/research/7fda0e28-5773-4e5b-b31b-8bdc6d217259/small/14420.jpg)
research Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs
Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.
research Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases
A protein called lfTSLP is important in causing allergic and other skin diseases and could be a target for treatment.
![Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.](/images/research/9bc1599a-86f3-49f2-b3d7-94be3f1523d8/small/2369.jpg)
research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.
GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.
![Acanthosis Nigricans during an HAIR-AN syndrome: "The Tree That Hides the Forest"](/images/research/8019464b-795c-432f-8329-7c0be03ccc4a/small/18312.jpg)
research Acanthosis Nigricans during an HAIR-AN syndrome: "The Tree That Hides the Forest"
The case shows skin changes can indicate deeper health issues like insulin resistance, which are challenging to manage.
![Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell?](/images/research/15285958-1411-4aad-92b9-fef174bb7ea1/small/19969.jpg)
research Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell?
New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
![DETERMINATION OF PERMEATION PATHWAY OF GENTAMICIN INTO PIG’S EAR SKIN](/images/research/0f0b507a-0196-4999-acae-6fac06816e4f/small/33978.jpg)
research DETERMINATION OF PERMEATION PATHWAY OF GENTAMICIN INTO PIG’S EAR SKIN
Gentamicin penetrates pig skin better through open hair follicles than blocked ones.
![Touch Receptors Undergo Rapid Remodeling in Healthy Skin](/images/research/d13a01b7-6bcf-4ec8-8d01-9573224e9343/small/19582.jpg)
research Touch Receptors Undergo Rapid Remodeling in Healthy Skin
Touch sensitivity in mouse skin decreases during hair growth due to changes in touch receptors.
![Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled “banana-shaped” shell](/images/research/2a3b01d7-1904-48f5-96b1-e2dcef365e2b/small/28514.jpg)
research Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled “banana-shaped” shell
Certain drugs change freshwater snail shells to a "banana" shape.
![The effect of night shift work on the expression of clock genes in beard hair follicle cells](/images/research/7a0877e9-a104-4e76-b9ab-9019a7654505/small/34870.jpg)
research The effect of night shift work on the expression of clock genes in beard hair follicle cells
Night shift work disrupts the body's natural clock genes.
![Regulated Proenkephalin Expression in Human Skin and Cultured Skin Cells](/images/research/b19c22e8-a06f-4002-9339-1c7285043c07/small/34945.jpg)
research Regulated Proenkephalin Expression in Human Skin and Cultured Skin Cells
Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.
![Androgen binding profiles of two distinct nuclear androgen receptors in Atlantic croaker (Micropogonias undulatus)](/images/research/d457036c-bf8e-4f08-84bd-5edbf39fdb2f/small/12615.jpg)
research Androgen binding profiles of two distinct nuclear androgen receptors in Atlantic croaker (Micropogonias undulatus)
Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.
![Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with Alopecia](/images/research/4436a32d-2949-41a7-9a1f-6d5ef937777c/small/36104.jpg)
research Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with Alopecia
The R343H mutation in the VDR gene causes vitamin D-resistant rickets with alopecia by impairing specific gene activity.