A Novel Tetrapeptide for the Treatment of Hair Loss Identified in Ginseng Berry: In Silico Characterization and Molecular Docking with TGF-β2

    December 2022 in “ Journal of Plant Biotechnology/Sigmul saengmyeong gong haghoeji/Journal of plant biotechnology ”
    Sung‐Gyu Lee, Sang Moon Kang, Hunseung Kang
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    TLDR A new peptide from ginseng berries may help prevent hair loss by promoting cell growth and reducing stress damage.
    The research explored the impact of peptides derived from ginseng berries and their modified versions on hair loss. These peptides were found to stimulate cell growth in DP and HaCaT cells at concentrations of 50 and 100 μg/mL, and also reduced ROS generation caused by H2O2-induced oxidative stress. The peptide MAGH was found to bind effectively with TGF-β2, a protein associated with hair loss, potentially inhibiting it and thus helping prevent hair loss. This interaction involved an H-bond with Ser356, Ser357, Ser382, and hydrophobic interactions with Leu385, with a minimum binding energy of 6.5 kcal/mol.
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