101 citations
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January 1997 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses neural mechanisms involved in hair growth control, focusing on piloneural interactions, but reports no clinical findings; the authors suggest further exploration for managing hair growth disorders.
397 citations
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February 2004 in “British Journal of Dermatology” This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.
18 citations
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January 1994 in “Skin Pharmacology and Physiology” This review discusses the enzyme levels involved in dihydrotestosterone formation in androgenetic alopecia patients and reports no new results; the authors suggest these differences may lead to better treatments for men and women.
9 citations
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December 2013 in “Toxicological Research” This study found that Chamaecyparis obtusa oil increased hair follicle cell proliferation and maintained the anagen phase in mice, suggesting a potential for promoting hair growth.
In this study, researchers found that crude extracts from Avicennia marina and its component avicequinone C inhibit mechanisms contributing to androgenic alopecia in vitro, including 5α-reductase activity and DHT-AR interactions, potentially promoting hair growth and delaying the catagen phase in human dermal papilla cells.
104 citations
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January 2023 in “Journal of Clinical Medicine” This review evaluates the hair cycle's phases and the factors influencing the transition between anagen and telogen, advocating for a holistic approach to addressing hair loss, though no specific results are reported.
25 citations
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April 2015 in “Current problems in dermatology” This study observed that repeated shaving and topical treatments, particularly TPA, stimulated hair regrowth in C3H mice, while certain treatments like betamethasone valerate completely inhibited it.
January 2010 in “Bradford Scholars (University of Bradford)” This study found that microRNAs play key roles in regulating gene expression during the hair cycle in mice, impacting follicle growth and skin homeostasis through mechanisms involving major signalling pathways.
52 citations
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September 2017 in “Current Stem Cell Research & Therapy” This review examines the effects of adipose-derived stem cells and their secreted factors on hair growth stimulation in laboratory and animal models, suggesting their potential as therapeutic agents for hair loss treatment.
3 citations
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July 2015 in “International journal of pharmacology” In this study, Natural Plant Extracts (NPE) promoted hair growth in mice by stimulating anagen growth and upregulating relevant gene expression, compared to controls with saline.
January 2020 in “Journal of Clinical Dermatology” This study found that oral dutasteride significantly increased hair density but not thickness in women with female-pattern hair loss, and identified a mechanism involving β-catenin activation.
3 citations
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September 2021 in “Journal of Food Science and Nutrition” This study found that red ginseng extract may stimulate hair growth in a mouse model by enhancing dermal papilla cell proliferation and activating skin antioxidant defenses.
May 2022 in “Research Square (Research Square)” In this study, components like vitamin E, β-sitosterol, and linoleic acid in the kernel of Prunus mira Koehne were reported to promote hair growth in mice, possibly through the Wnt/β-catenin pathway.
73 citations
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June 2001 in “Endocrinology” In this study, researchers found that disrupting the PRL gene in mice led to earlier hair molting, especially in females, suggesting that PRL inhibits murine hair cycle events.
26 citations
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March 1987 in “Journal of the American Academy of Dermatology” This study suggests that topical minoxidil may aid hair regrowth in alopecia areata through synergistic effects on follicular epithelium and lymphocyte-mediated immunological responses, alongside its vasodilatory properties.
14 citations
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June 2001 in “Endocrinology” This study found that disrupting the PRL gene in mice alters the timing of hair cycling events, causing earlier molts and changes in hair characteristics, particularly affecting female mice more significantly.
1 citations
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January 2010 in “Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover)” 
October 2024 in “International Journal of Molecular Sciences” In this study, Rosa rugosa water extract improved hair length and thickness in a mouse model of DHT-induced alopecia by enhancing the expression of hair growth-promoting factors while inhibiting growth-suppressive proteins, suggesting its potential as a natural therapy for hair loss prevention.
January 2010 in “Xiandai yaowu yu linchuang” In this mouse study, Yangxue Shengfa Capsules were associated with promoted hair growth by increasing VEGF levels, hair follicle number, and skin blood vessels.
January 2000 in “Linchuang pifuke zazhi” This study demonstrated that cyclosporin A upregulated mRNA expression of HGF and VEGF in cultured mouse vibrissa follicles.
7 citations
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November 2022 in “Communications biology” This study found that injecting keratin into the skin of mice promoted hair growth, potentially through keratin's interaction with hair-forming cells and changes in the microenvironment.
April 2025 in “Journal of Pharmacy and Pharmacology” This study reviewed how certain phytochemicals can stimulate hair follicles, promote keratinocyte proliferation, and engage specific signaling pathways like Wnt/β-catenin and AKT, suggesting these natural compounds may offer safer alternatives for promoting hair growth. However, challenges in bioavailability and formulation standardization remain to be addressed.
51 citations
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January 2003 in “Hormone Research in Paediatrics” This review discusses hormonal influences on hair growth and suggests that understanding hormone-gene interactions may improve treatment of hirsutism and alopecia, but reports no new clinical findings.
24 citations
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January 2015 in “Evidence-based Complementary and Alternative Medicine” In this study, Polygonum multiflorum Radix promoted hair growth in mice, with oral administration being more effective, likely through FGF-7, while topical application favored SHH-related mechanisms.
14 citations
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March 2019 in “Journal of Cosmetic Dermatology” This laboratory study found that activated platelet‐rich plasma supernatant enhanced hair growth signaling pathways in cultured human dermal papilla cells, suggesting potential for treating androgenic alopecia.
2 citations
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January 2023 in “Pharmaceuticals” This review discusses factors affecting hair health, types of alopecia, and the potential of phytochemicals in managing hair loss but reports no new clinical results; it highlights the need for further studies.
1 citations
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August 1989 in “Archives of Dermatology” This article reviews recent discoveries about the role of the nitroxide free radical NO in vascular physiology and suggests potential implications for minoxidil's vasodilatory action, but reports no new clinical findings.
April 2026 in “Asian Journal of Research in Pharmaceutical Sciences” This review highlights the promising potential of Semecarpus anacardium Linn. in promoting hair growth due to its antioxidant and anti-inflammatory properties but emphasizes the need for further human clinical trials and safe formulation practices due to its associated toxicity in raw form.
September 2025 in “Current Issues in Molecular Biology” This study highlights IGF-1's role in promoting hair follicle proliferation, vascularization, and growth, suggesting its potential as a treatment target for hair loss disorders like androgenetic alopecia, though more research on delivery methods and long-term effects is needed.
This study found that Chrysanthemum zawadskii extract may promote hair growth by inducing an earlier conversion of telogen to anagen and increasing the proliferation of dermal papilla cells in mice and human hair follicle cultures.