Biochemical Mechanisms Regulating Human Hair Growth

    January 1994 in “ Skin Pharmacology and Physiology ”
    Marty E. Sawaya
    TLDR Androgens shorten hair growth phases, causing finer hair and more severe hair loss in men.
    The document discussed the biochemical mechanisms regulating human hair growth, focusing on the role of androgens like testosterone and dihydrotestosterone in androgenetic alopecia. It highlighted that these hormones can shorten the anagen growth phase, leading to finer hair texture. The study evaluated enzymes such as 5a-reductase and cytochrome P-450 aromatase in hair follicles and sebaceous glands, finding differences in enzyme levels between men and women and between different scalp regions. These variations might explain the more severe hair loss patterns in men compared to women, suggesting that understanding these differences could lead to more effective treatments for androgenetic alopecia.
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