Novel Mechanism of Action of Dutasteride for Inducing Hair Growth in Patients with Female-Pattern Hair Loss

January 2020 in “ Journal of Clinical Dermatology ”

Kim soojung, Yul-Lye Hwang, Su-Hyuk Yim, Hong Dongkyun, Chong Won Choi, Kyung Hae Jung, Seo Young Joon, Chang Duck Kim, Jung-Min Shin, Leslie A. Young

dutasteride Female-pattern hair loss vertex hair density occipital hair density β-catenin dermal papilla cells vascular endothelial growth factor 5α-reductase inhibitors FPHL DPCs VEGF

TLDR Dutasteride helps increase hair density in patients with female-pattern hair loss by activating a new growth mechanism.

The study, conducted three years ago, evaluated the clinical utility of dutasteride in 24 patients with Female-pattern hair loss (FPHL). The results showed that the mean vertex hair density significantly increased from 67±14 to 76±13/cm2 (p=0.001) and the mean occipital hair density increased from 89±11 to 94±13/cm2 (p=0.012) after dutasteride treatment. However, the mean hair thickness did not increase. Dutasteride treatment also led to an increase in β-catenin activity in primary cultures of human dermal papilla cells (DPCs), and the mRNA level of vascular endothelial growth factor increased. The study concluded that dutasteride promotes hair growth through a novel mechanism, supporting the potential clinical application of 5α-reductase inhibitors for the treatment of FPHL.

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community COMPLETE OVERVIEW of the Treatment of androgenetic alopecia in men

26 upvotes 11 years ago

Male androgenetic alopecia is commonly treated with topical minoxidil and oral finasteride, both requiring continuous use. Other options include hair restoration surgery, dutasteride, light therapy, and camouflaging agents.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

in Progress Pictures 224 upvotes 1 year ago

A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Doctor says i shouldn't take fin because its "hormonal"

in Finasteride/Dutasteride 106 upvotes 1 year ago

A user in Turkey was advised by a dermatologist to avoid finasteride due to its hormonal effects and was prescribed minoxidil, shampoo, and vitamins instead. The user is considering seeking another doctor's opinion or buying finasteride directly from a pharmacy.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 3 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

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