Study on the Mechanism of Cyclosporin A in Stimulating Hair Growth

January 2000 in “ Linchuang pifuke zazhi ”

Fan Wei

cyclosporin A hair growth HGF VEGF mRNA vibrissa follicles RT-PCR

TLDR Cyclosporin A helps hair grow by increasing certain growth factors.

The study investigated the effects of cyclosporin A on hair growth by examining mRNA expressions of HGF and VEGF in cultured mouse vibrissa follicles. Using RT-PCR and semi-quantitative RT-PCR, it was found that on the sixth day of culture, the expressions of HGF and VEGF mRNA were still detectable in the follicles treated with cyclosporin A, unlike in the control group. This indicated that cyclosporin A upregulated the mRNA expression of these growth factors, suggesting a mechanism by which it stimulated hair growth.

View this study on en.cnki.com.cn →

Discuss this study in the Community →

Related Community Posts Join

6 / 22 results

community Forgotten 'Total Revival' Stack

in Research/Science 42 upvotes 7 months ago

Cyclosporine A is discussed as a powerful hair growth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.

community Why isn't anyone using Way-316606? If it works then it grows a full head of hair back on most people

in Treatment 134 upvotes 9 months ago

Way-316606 is considered a potential hair loss treatment but is avoided due to safety concerns and lack of research. Minoxidil and Finasteride are preferred as established treatments.

community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

in Research/Science 99 upvotes 1 year ago

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

community Any treatments in development that could theoretically give complete regrowth?

in Research/Science 7 upvotes 7 months ago

New hair loss treatments like PP-405, AMP-303, and SCUBE3 are being discussed, but none are confirmed to fully restore hairlines. Current treatments like Minoxidil, Finasteride, and RU58841 are still widely used, with some hope for future advancements in hair regrowth.

community The most nuclear stack possible

in Satire 45 upvotes 8 months ago

A user humorously suggests an extreme hair loss treatment regimen involving multiple medications and therapies, including Dutasteride, Minoxidil, RU58841, and others, claiming it would prevent hair loss but with potential side effects like gynecomastia. The conversation highlights concerns about safety, side effects, and the effectiveness of such a comprehensive approach.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 3 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

Similar Research

5 / 1000+ results

research Cyclosporine A Stimulated Hair Growth from Mouse Vibrissae Follicles in an Organ Culture Model

11 citations , September 2012 in “Journal of Nanjing Medical University”

Cyclosporine A was found to increase hair growth in mouse whisker follicles.

research Molecular Biology of Hair Morphogenesis: Development and Cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

research The Biology of Hair Growth

10 citations , January 2009 in “Elsevier eBooks”

Hair growth is influenced by hormones and goes through different phases; androgens can both promote and inhibit hair growth depending on the body area.

Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

research Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

49 citations , March 2014 in “Journal of Investigative Dermatology”

Using the drugs AMD3100 and Tacrolimus together greatly improves skin healing and hair growth after a deep skin cut by increasing stem cells in the wound.

research Human Hair Follicle: An Update on Biology and Perspectives in Hair Growth Disorders Treatment

2 citations , January 2014 in “Hair therapy & transplantation”

New treatments for hair growth disorders are needed due to limited current options and complex hair follicle biology.