355 citations
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August 2013 in “Acta Biomaterialia” This study found that a nanoparticle-in-nanofiber system significantly accelerated wound healing in rats by promoting angiogenesis and tissue regeneration more effectively than a commercial wound dressing.
2 citations
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September 2016 in “Journal of Dermatological Science” This study reported that squarticles, nanoparticle carriers made from sebum-derived lipids, significantly enhanced minoxidil delivery to hair follicles in vitro, increasing follicular uptake sevenfold and minimizing systemic absorption compared to a free control solution, while showing good skin tolerability.
January 2023 in “Open Life Sciences” This study found that VEGFR-2 activation may play a role in hair follicle differentiation, proliferation, and apoptosis by co-expressing with several key proteins in normal human scalp skin.
222 citations
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August 2009 in “Experimental Dermatology” This review discusses the role of stem cells in cutaneous wound healing and reports no clinical results; the authors highlight the need for better understanding of underlying mechanisms for future therapies.
202 citations
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August 2007 in “Biomaterials” This review discusses advancements in artificial skin for wound treatment and reports no new clinical findings; the authors highlight the potential of new biomaterials to enhance future skin replacement therapies.
18 citations
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July 2012 in “Cell Biology International Reports” This study suggests that human mesenchymal stem cells have the potential to differentiate into dermal papilla cells both in vitro and in vivo.
316 citations
,
June 2017 in “Stem Cell Research & Therapy” This review covers the potential of SVF and ADSC therapies in regenerative medicine and highlights the challenges of regulation and efficacy, without reporting new clinical results.
33 citations
,
May 2006 in “Journal of Investigative Dermatology” This study found that high levels of parathyroid hormone-related protein expression can result in the production of shorter hair shafts, likely through effects on angiogenesis.
10 citations
,
August 2020 in “Journal of Bioscience and Bioengineering” This study reports that using activated platelet-rich plasma releasate in the preparation of bioengineered hair follicle germs enhanced follicular gene expression and significantly improved hair regeneration in vitro.
3 citations
,
January 2022 in “Burns & Trauma” This study found that CTHRC1 is crucial for sweat gland function and vascular network integrity in mice, and its administration improved sweat gland performance by reconstructing nearby blood vessels.
This study found that γδ T cells play a role in regulating stromal behavior, influencing the composition and vascularity of fibrotic tissues during the foreign body response.
1 citations
,
February 2022 in “The Journal of Urology” This article discusses the potential mechanism by which 5α-reductase inhibitors might offer protection against SARS-CoV-2, emphasizing possible roles of dehydroepiandrosterone and its impact on nitric oxide bioavailability, but reports no new experimental results.
1 citations
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January 2013 in “China Animal Husbandry & Veterinary Medicine” This study found a strong positive correlation between vascular endothelial growth factor expression and microvessel density in the hair follicles of Liaoning cashmere goats during different fetal periods.
This study found that a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) significantly accelerated wound closure and improved healing in diabetic mice, also enhancing nerve and blood vessel formation compared to controls.
December 2012 in “Journal of Dermatological Science” In this study, estradiol was found to increase VEGF expression in cultured dermal papilla cells at physiological levels similar to pregnancy, suggesting that declining estrogen might contribute to female pattern hair loss in older Japanese women.
28 citations
,
August 2014 in “Journal of Assisted Reproduction and Genetics” This study found that the VEGF +405G/C polymorphism may be an inheritable risk factor for polycystic ovary syndrome in south Indian women.
16 citations
,
October 2018 in “Biochemical and Biophysical Research Communications” In this study, sildenafil was found to enhance human dermal papilla cell proliferation and promote hair growth in mice, suggesting potential use in alopecia treatment.
6 citations
,
January 2022 in “Journal of Investigative Dermatology” This study found that androgen receptor signaling is linked to blood vessel regression in the dermal papilla of balding scalp, contributing to hair follicle miniaturization in androgenetic alopecia.
5 citations
,
March 2017 in “Biomedical and Pharmacology Journal” This article discusses the concept of telogen effluvium, introduced in 1961, characterized by diffuse scalp hair loss due to various triggers, and reports no new clinical findings.
1 citations
,
December 2022 in “Current Issues in Molecular Biology” This study found that orally administered Annurca apple extract improved hair length, thickness, weight, and density in mice, while also increasing the expression of hair growth-related genes and proteins, suggesting potential as a natural treatment for hair loss.
May 2026 in “Stem Cell Research & Therapy” This study found that exosomes derived from dental pulp mesenchymal stem cells (DPSC-Exos) significantly promoted hair regrowth and follicle density in a mouse model of androgenetic alopecia, showing similar efficacy to minoxidil by activating pathways that improve follicular vascularization and dermal papilla cell function.
April 2025 in “Journal of Ethnopharmacology” This study elucidated the multi-component and multi-target mechanisms by which TR and Am may provide therapeutic benefits for treating androgenetic alopecia.
April 2024 in “Bioactive materials” This study found that a microneedle system delivering VEGF and Ritlecitinib improved hair regeneration in mice with androgenetic alopecia, showing faster anagen onset and better hair quality compared to minoxidil.
June 2023 in “Current Issues in Molecular Biology” In this study, the alcoholic extract DN106212 from Centipeda minima was shown to be more effective in promoting hair growth in C57BL/6 mice compared to dimethyl sulfoxide and tofacitinib, suggesting its potential as a natural hair growth agent.
June 2023 in “Food frontiers” In this animal study, researchers observed that ginsenoside CK significantly reduced hair loss, improved sexual organ health, and encouraged hair growth in mice with androgenetic alopecia by modulating key signaling pathways and normalizing hormone metabolism, highlighting its potential as a therapeutic agent.
January 2022 in “Journal of St. Marianna University” This study investigated how secretions from cultured human hair follicle-derived keratinocytes affect gene expression in human follicle dermal papilla cells to understand their signaling interactions.
This study found that Avicennia marina extract and its active compound avicequinone C inhibit enzymes and receptors related to androgenic alopecia, potentially supporting hair growth in cultured dermal papilla cells.
1 citations
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August 2023 in “Composites Part B: Engineering” In this study, researchers developed a composite electrospun wound dressing containing strontium zinc silicon bioceramics, which significantly activated hair follicle stem cells and promoted hair follicle and capillary regeneration in deep burn wounds, suggesting a promising approach for burn wound healing.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers observed that blood vessel maturation in mice involves neonatal endothelial cells expanding the capillary network through vessel regression and angiogenesis, with adult cells later maintaining stability and repair through specific signaling pathways.
June 2023 in “Frontiers in Cardiovascular Medicine” This review identified two promising therapeutic targets for drug repurposing to treat refractory angina in patients with angina pectoris without obstructive coronary artery disease: endothelin-1 receptor blockers and soluble guanylate cyclase stimulators.