TLDR CTHRC1 helps sweat glands recover by rebuilding nearby blood vessels.
The study investigated the role of Collagen triple helix repeat containing-1 (CTHRC1) in the functional recovery of sweat glands (SGs) and their adjacent microvascular networks in mice. It was found that CTHRC1 is crucial for SG function, as its deletion led to disordered and reduced microvascular networks around SGs and decreased expression of vascular development genes. By replenishing CTHRC1 in Cthrc1−/− mice, researchers observed enhanced SG function through the reconstruction of the adjacent vascular network. This study suggested that CTHRC1 could be a novel target for restoring or regenerating SG function in vivo.
2 citations
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July 2021 in “Biochemical and Biophysical Research Communications” CTHRC1 helps hair grow back, and plantar dermis mixture boosts it.
24 citations
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January 2018 in “Development” Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.
265 citations
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July 2012 in “Cell” The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.
2 citations
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July 2021 in “Biochemical and Biophysical Research Communications” CTHRC1 helps hair grow back, and plantar dermis mixture boosts it.
August 2023 in “Military Medical Research” Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.
9 citations
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January 2023 in “International Journal of Biological Sciences” CTHRC1 is essential for healing and preventing heart rupture after a heart attack.
24 citations
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January 2018 in “Development” Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.
177 citations
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March 2018 in “International Journal of Molecular Sciences” mTOR inhibitors may help treat lung fibrosis.
