Dental Pulp Stem Cell Exosomes Promote Angiogenesis via the PI3K/Akt Signaling Pathway to Treat Androgenetic Alopecia

May 2026 in “ Stem Cell Research & Therapy ”

WangYu Luo, Yue Shen, WanNing Yu, Le Zhao, Miaomiao Wu, L Xu, Ziyan Liu, Liu Yang, Xi Zhang

New to Minoxidil? There is a guide in the encyclopedia. Read the guide →

dental pulp stem cell exosomes DPSC-Exos angiogenesis PI3K/Akt signaling pathway androgenetic alopecia AGA DHT hair regrowth hair follicle density dermal thickness minoxidil VEGFA perifollicular vascular network dermal papilla cells pro-angiogenic factors PI3K inhibition stem cell exosomes hair loss Rogaine vascular endothelial growth factor A

Studysummary This study found that exosomes derived from dental pulp mesenchymal stem cells (DPSC-Exos) significantly promoted hair regrowth and follicle density in a mouse model of androgenetic alopecia, showing similar efficacy to minoxidil by activating pathways that improve follicular vascularization and dermal papilla cell function.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on link.springer.com →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

Dual Effects of HA-iMSC-Exosomes in Human Follicle Dermal Papilla Cells on Androgenic Alopecia in Vitro Model

research 1494 Dual effects of HA-iMSC-exosomes in human follicle dermal papilla cells (HFDPC) on androgenic alopecia in vitro model

April 2023 in “Journal of Investigative Dermatology”

This study found that exosomes from hyaluronic acid-primed mesenchymal stem cells may promote hair growth in androgenetic alopecia by improving hair follicle cell function and restoring key signaling pathways disrupted by DHT.

research Tissue Repair Mechanisms of Dental Pulp Stem Cells: A Comprehensive Review from Cutaneous Regeneration to Mucosal Healing

3 citations , July 2025 in “Current Issues in Molecular Biology”

This review discusses how dental pulp stem cells and their derivatives may accelerate skin wound healing by modulating inflammation, promoting angiogenesis, optimizing extracellular matrix structure, and enhancing tissue formation, with implications for translating these findings into therapies for skin and mucosal repair.

Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization, and Comparative Analysis of Their In Vitro Wound Healing Potential

research Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization and Comparative Analysis of Their In Vitro Wound Healing Potential

May 2025 in “International Journal of Molecular Sciences”

This study found that exosomes and secretome derived from rat hair follicle stem cells show promising potential for wound healing and tissue repair, demonstrating significant wound closure and suggesting their broader applicability in regenerative medicine.

research Stem cell secretome as a new booster for regenerative medicine

54 citations , August 2019 in “Bioscience trends”

This review discusses the potential of stem cell secretome in regenerative medicine and suggests that its paracrine effects, rather than direct cell replacement, may drive therapeutic benefits.

Exosomes and Their Bioengineering Strategies in Cutaneous Wound Healing and Related Complications: Current Knowledge and Future Perspectives

research Exosomes and Their Bioengineering Strategies in the Cutaneous Wound Healing and Related Complications: Current Knowledge and Future Perspectives

72 citations , January 2023 in “International Journal of Biological Sciences”

This review discusses recent advances in the therapeutic potential of exosomes for wound healing, highlighting their benefits and challenges but reports no new clinical results.