Tissue Repair Mechanisms of Dental Pulp Stem Cells: A Comprehensive Review from Cutaneous Regeneration to Mucosal Healing

    July 2025 in “ Current Issues in Molecular Biology ”
    Jing He, Jiao Fu, Ruoxuan Wang, Xiaojing Liu, Juming Yao, Wenbo Xing, Xinxin Wang, Yan He
    TLDR Dental pulp stem cells can help heal skin and mucosal wounds effectively.
    This review highlights the potential of dental pulp stem cells (DPSCs) in tissue repair, particularly in skin and mucosal healing. DPSCs contribute to wound healing by regulating inflammation, promoting angiogenesis, optimizing extracellular matrix structure, and enhancing granulation tissue formation. The review also discusses factors like oxidative stress and mechanical stimulation that can enhance DPSCs' effectiveness. Additionally, combining DPSCs with drugs may amplify their therapeutic effects. The findings suggest promising applications for DPSCs in treating chronic wounds and mucosal injuries, bridging basic research with clinical practice and advancing regenerative medicine strategies.
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