Strontium Zinc Silicate Bioceramic Composite Electrospun Fiber Membrane for Hair Follicle Regeneration in Burn Wounds

The study developed a composite electrospun wound dressing containing strontium zinc silicon bioceramics (Sr2ZnSi2O7, SZS) for hair follicle regeneration in burn wounds. The dressing efficiently released Sr2+, Zn2+, and SiO32− ions, which synergistically created a beneficial microenvironment for promoting rapid wound healing and hair follicle regeneration. The dressing was tested on deep second-degree skin burn defects in mice, and the results verified its therapeutic effects. The study also confirmed the synergistic effects and mechanisms of Sr2+, Zn2+, and SiO32− in stimulating hair follicle regeneration and angiogenesis using human umbilical vein endothelial cells and rat hair follicle stem cells. This development addresses a significant issue in burn wound management, as hair follicles are easily destroyed by hyperthermia and replaced with scar tissue during the healing process.