A Regenerative Stem Cell-Derived Matrix Accelerates Functional Dermal Wound Repair in a Preclinical Diabetic Model

    February 2026
    Colette A. Abbey, Joshua Benton, Erin Goebel … Carl A. Gregory
    Studysummary This study found that a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) significantly accelerated wound closure and improved healing in diabetic mice, also enhancing nerve and blood vessel formation compared to controls.
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    Research cited in this study 4

    1. Recent Advances in the Role of Neuroregulation in Skin Wound Healing Burns & Trauma · 2024
    2. Diabetes Mellitus Inhibits Hair Follicle Regeneration by Inducing Macrophage Reprogramming-Mediated Pyroptosis Journal of Inflammation Research · 2024
    3. Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice: A Mechanistic Systematic Review International Journal of Molecular Sciences · 2022
    4. Skin Wound Healing in Humans and Mice: Challenges in Translational Research Journal of Dermatological Science · 2017