A Regenerative Stem Cell-Derived Matrix Accelerates Functional Dermal Wound Repair in a Preclinical Diabetic Model

The study investigates the effects of a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) on wound healing in diabetic mice. A single dose of rECM significantly accelerated wound closure compared to controls and improved histological healing scores in a dose-dependent manner. The treatment promoted rapid resolution of granulation tissue, enhanced peripheral nerve formation, and improved vascular maturation, as evidenced by increased blood vessel size and density. Additionally, in a 3D angiogenic sprouting model, rECM facilitated endothelial invasion and collagen matrix contraction. These findings suggest that rECM effectively accelerates the healing of diabetic skin wounds by enhancing tissue remodeling and vascular and nerve development.