TLDR The VEGF +405G allele may increase the risk of PCOS in South Indian women.
The study examined the relationship between the VEGF +405G/C polymorphism and the risk of polycystic ovary syndrome (PCOS) in 126 South Indian women with PCOS and 130 controls. It found that the +405G/G genotype and the +405G allele were significantly more common in the PCOS group, indicating that this polymorphism might be a genetic risk factor for PCOS in this population. The -460C/T SNP showed no significant association with PCOS. The study suggests the VEGF gene, particularly the +405G allele, could be involved in the development of PCOS, although it calls for larger studies to validate these results.
59 citations,
March 2013 in “European Journal of Obstetrics & Gynecology and Reproductive Biology” People with polycystic ovary syndrome have a higher chance of having chronic thyroiditis.
991 citations,
January 2011 in “Nature Reviews Endocrinology” The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.
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December 2003 in “Human Reproduction” The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
5 citations,
January 2020 in “Bioscience Reports” Certain changes in the VEGF gene can increase or decrease the risk of polycystic ovary syndrome.
200 citations,
October 2009 in “European journal of endocrinology” Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.
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July 2016 in “Gynecological Endocrinology” Obese and non-obese women with PCOS have higher heart risk markers, especially if they are obese.
308 citations,
December 2018 in “PLOS Genetics” The research found that PCOS has common genetic factors regardless of how it is diagnosed and is linked to metabolic and reproductive issues.
