TLDR The VEGF +405G allele may increase the risk of PCOS in South Indian women.
The study examined the relationship between the VEGF +405G/C polymorphism and the risk of polycystic ovary syndrome (PCOS) in 126 South Indian women with PCOS and 130 controls. It found that the +405G/G genotype and the +405G allele were significantly more common in the PCOS group, indicating that this polymorphism might be a genetic risk factor for PCOS in this population. The -460C/T SNP showed no significant association with PCOS. The study suggests the VEGF gene, particularly the +405G allele, could be involved in the development of PCOS, although it calls for larger studies to validate these results.
59 citations
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March 2013 in “European Journal of Obstetrics & Gynecology and Reproductive Biology” People with polycystic ovary syndrome have a higher chance of having chronic thyroiditis.
991 citations
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January 2011 in “Nature Reviews Endocrinology” The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.
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December 2003 in “Human Reproduction” The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
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January 2020 in “Bioscience Reports” Certain changes in the VEGF gene can increase or decrease the risk of polycystic ovary syndrome.
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October 2009 in “European journal of endocrinology” Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.
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September 2015 in “Clinical Endocrinology” Women with PCOS have higher levels of a certain growth factor, which can be reduced by taking metformin.
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July 2016 in “Gynecological Endocrinology” Obese and non-obese women with PCOS have higher heart risk markers, especially if they are obese.
308 citations
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December 2018 in “PLOS Genetics” The research found that PCOS has common genetic factors regardless of how it is diagnosed and is linked to metabolic and reproductive issues.
