Serum Vascular Endothelial Growth Factor B Is Elevated in Women With Polycystic Ovary Syndrome and Can Be Decreased With Metformin Treatment

    September 2015 in “ Clinical Endocrinology ”
    Fang Cheng, Lu Zhao, Yuanyuan Wu, Tiantian Huang, Gangyi Yang, Zhanyu Zhang, Yijia Wu, Fang Jia, Jinlin Wu, Chen Chen, Dongfang Liu
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    Studysummary This study found that women with polycystic ovary syndrome have higher serum VEGF-B levels, which are linked to insulin resistance and decrease after metformin treatment.
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    The study investigated serum vascular endothelial growth factor B (VEGF-B) in 103 women with polycystic ovary syndrome (PCOS) compared to 96 healthy controls, finding that VEGF-B levels were significantly higher in the PCOS group. These elevated levels were positively correlated with body mass index, body fat percentage, insulin resistance, and ß-cell function. After treatment with metformin, a significant reduction in VEGF-B levels and improvement in insulin resistance was observed in the PCOS group. The research suggests that VEGF-B is linked to insulin resistance in PCOS and that metformin can effectively lower VEGF-B levels and improve metabolic outcomes in these patients.
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