Evaluation of Cardiac Risk Marker Levels in Obese and Non-Obese Patients with Polycystic Ovaries

The study from July 16, 2016, investigated cardiac risk markers in 60 women with polycystic ovary syndrome (PCOS), divided into 30 obese (BMI > 30 kg/m²) and 30 non-obese (BMI < 30 kg/m²) individuals, and compared them with 30 age-matched healthy controls. It found that serum levels of C-reactive protein (CRP), homocysteine (Hcy), plasminogen activator inhibitor-1 (PAI-1), angiopoietin-like protein 6 (ANGPLT6), vascular endothelial growth factor (VEGF), and asymmetric dimethylarginine (ADMA) were significantly higher in both obese and non-obese PCOS patients than in controls, with more significant elevation in the obese group. This suggests an increased cardiovascular risk in women with PCOS, particularly in those who are obese.